CORIN (NM_001278585) Human Tagged ORF Clone

Specifications

Product Data
Type	Human Tagged ORF Clone
Tag	Myc-DDK
Synonyms	ATC2; CRN; Lrp4; PEE5; TMPRSS10
Vector	pCMV6-Entry
E. coli Selection	Kanamycin (25 ug/mL)
Mammalian Cell Selection	Neomycin
Sequence Data	ORF Nucleotide Sequence (showhide) >RC239804 representing NM_001278585 Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGAAACAGTCTCCTGCCCTCGCTCCGGAAGAGCGCTGCCGCAGAGCCGGGTCCCCAAAGCCGGTCTTGA GAGCTGATGACAATAACATGGGCAATGGCTGCTCTCAGAAGCTGGCGACTGCTAACCTCCTCCGGTTCCT ATTGCTGGTCCTGATTCCATGTATCTGTGCTCTCGTTCTCTTGCTGGTGATCCTGCTTTCCTATGTTGGT GCCTGTATGAACATCACCCACAGCCAGTGTCAGATGCTGCCCTACCACGCCACGCTGACACCTCTCCTCT CAGTTGTCAGAAACATGGAAATGGAAAAGTTCCTCAAGTTTTTCACATATCTCCATCGCCTCAGTTGCTA TCAACATATCATGCTGTTTGGCTGTACCCTCGCCTTCCCTGAGTGCATCATTGATGGCGATGACAGTCAT GGACTCCTGCCCTGTAGGTCCTTCTGTGAGGCTGCAAAAGAAGGCTGTGAATCAGTCCTGGGGATGGTGA ATTACTCCTGGCCGGATTTCCTCAGATGCTCCCAGTTTAGAAACCAAACTGAAAGCAGCAATGTCAGCAG AATTTGCTTCTCACCTCAGCAGGAAAACGGAAAGCAATTGCTCTGTGGAAGGGGTGAGAACTTTCTGTGT GCCAGTGGAATCTGCATCCCCGGGAAACTGCAATGTAATGGCTACAACGACTGTGACGACTGGAGTGACG AGGCTCATTGCAACTGCAGCGAGAATCTGTTTCACTGTCACACAGGCAAGTGCCTTAATTACAGCCTTGT GTGTGATGGATATGATGACTGTGGGGATTTGAGTGATGAGCAAAACTGTGCCTGTCACAGCCAGGGTCTG GTGGAATGCAGAAATGGACAATGTATCCCCAGCACGTTTCAATGTGATGGTGACGAGGACTGCAAGGATG GGAGTGATGAGGAGAACTGCAGCGTCATTCAGACTTCATGTCAAGAAGGAGACCAAAGATGCCTCTACAA TCCCTGCCTTGATTCATGTGGTGGTAGCTCTCTCTGTGACCCGAACAACAGTCTGAATAACTGTAGTCAA TGTGAACCAATTACATTGGAACTCTGCATGAATTTGCCCTACAACAGTACAAGTTATCCAAATTATTTTG GCCACAGGACTCAAAAGGAAGCATCCATCAGCTGGGAGTCTTCTCTTTTCCCTGCACTTGTTCAAACCAA CTGTTATAAATACCTCATGTTCTTTTCTTGCACCATTTTGGTACCAAAATGTGATGTGAATACAGGCGAG CATATCCCTCCTTGCAGGGCATTGTGTGAACACTCTAAAGAACGCTGTGAGTCTGTTCTTGGGATTGTGG GCCTACAGTGGCCTGAAGACACAGATTGCAGTCAATTTCCAGAGGAAAATTCAGACAATCAAACCTGCCT GATGCCTGATGAATATGTGGAAGAATGCTCACCTAGTCATTTCAAGTGCCGCTCAGGACAGTGTGTTCTG GCTTCCAGAAGATGTGATGGCCAGGCCGACTGTGACGATGACAGTGATGAGGAAAACTGTGGTTGTAAAG AGAGAGATCTTTGGGAATGTCCATCCAATAAACAATGTTTGAAGCACACAGTGATCTGCGATGGGTTCCC AGACTGCCCTGATTACATGGACGAGAAAAACTGCTCATTTTGCCAAGATGATGAGCTGGAATGTGCAAAC CATGCGTGTGTGTCACGTGACCTGTGGTGTGATGGTGAAGCCGACTGCTCAGACAGTTCAGATGAATGGG ACTGTGTGACCCTCTCTATAAATGTGAACTCCTCTTCCTTTCTGATGGTTCACAGAGCTGCCACAGAACA CCATGTGTGTGCAGATGGCTGGCAGGAGATATTGAGTCAGCTGGCCTGCAAGCAGATGGGTTTAGGAGAA CCATCTGTGACCAAATTGATACAGGAACAGGAGAAAGAGCCGCGGTGGCTGACATTACACTCCAACTGGG AGAGCCTCAATGGGACCACTTTACATGAACTTCTAGTAAATGGGCAGTCTTGTGAGAGCAGAAGTAAAAT TTCTCTTCTGTGTACTAAACAAGACTGTGGGCGCCGCCCTGCTGCCCGAATGAACAAAAGGATCCTTGGA GGTCGGACGAGTCGCCCTGGAAGGTGGCCATGGCAGTGTTCTCTGCAGAGTGAACCCAGTGGACATATCT GTGGCTGTGTCCTCATTGCCAAGAAGTGGGTTCTGACAGTTGCCCACTGCTTCGAGGGGAGAGAGAATGC TGCAGTTTGGAAAGTGGTGCTTGGCATCAACAATCTAGACCATCCATCAGTGTTCATGCAGACACGCTTT GTGAAGACCATCATCCTGCATCCCCGCTACAGTCGAGCAGTGGTGGACTATGACATCAGCATCGTTGAGC TGAGTGAAGACATCAGTGAGACTGGCTACGTCCGGCCTGTCTGCTTGCCCAACCCGGAGCAGTGGCTAGA GCCTGACACGTACTGCTATATCACAGGCTGGGGCCACATGGGCAATAAAATGCCATTTAAGCTGCAAGAG GGAGAGGTCCGCATTATTTCTCTGGAACATTGTCAGTCCTACTTTGACATGAAGACCATCACCACTCGGA TGATATGTGCTGGCTATGAGTCTGGCACAGTTGATTCATGCATGGGTGACAGCGGTGGGCCTCTTGTTTG TGAGAAGCCTGGAGGACGGTGGACATTATTTGGATTAACTTCATGGGGCTCCGTCTGCTTTTCCAAAGTC CTGGGGCCTGGCGTTTATAGTAATGTGTCATATTTCGTCGAATGGATTAAAAGACAGATTTACATCCAGA CCTTTCTCCTAAAC ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA Protein Sequence (showhide) >RC239804 representing NM_001278585 Red=Cloning site Green=Tags(s) MKQSPALAPEERCRRAGSPKPVLRADDNNMGNGCSQKLATANLLRFLLLVLIPCICALVLLLVILLSYVG ACMNITHSQCQMLPYHATLTPLLSVVRNMEMEKFLKFFTYLHRLSCYQHIMLFGCTLAFPECIIDGDDSH GLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICFSPQQENGKQLLCGRGENFLC ASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCACHSQGL VECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQ CEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGE HIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVL ASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECAN HACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQEILSQLACKQMGLGE PSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSKISLLCTKQDCGRRPAARMNKRILG GRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRF VKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWGHMGNKMPFKLQE GEVRIISLEHCQSYFDMKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKV LGPGVYSNVSYFVEWIKRQIYIQTFLLN TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Restriction Sites	SgfI-MluI      Cloning Scheme for this gene      Plasmid Map
ACCN	NM_001278585
ORF Size	2814 bp
OTI Disclaimer	The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
OTI Annotation	This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001278585.1, NP_001265514.1
RefSeq Size	4703 bp
RefSeq ORF	2817 bp
Locus ID	10699
UniProt ID	Q9Y5Q5
Protein Families	Druggable Genome, Protease, Transmembrane
MW	105.6 kDa
Gene Summary	This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

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