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Sorcs2 (NM_030889) Mouse Tagged Lenti ORF Clone
CAT＃: MR216425L3
- LentiORF®
Lenti ORF clone of Sorcs2 (Myc-DDK-tagged) - Mouse sortilin-related VPS10 domain containing receptor 2 (Sorcs2)
"NM_030889" in other vectors (4)
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CNY 12,070.00
Product images
CNY 600.00
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
| Tag | Myc-DDK |
| Synonyms | mKIAA1329; N28137 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| E. coli Selection | Chloramphenicol (34 ug/mL) |
| Mammalian Cell Selection | Puromycin |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR216425).
|
| Restriction Sites |
AscI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_030889 |
| ORF Size | 3480 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_030889.2, NP_112151.2 |
| RefSeq Size | 5722 bp |
| RefSeq ORF | 3480 bp |
| Locus ID | 81840 |
| UniProt ID | Q9EPR5 |
| Gene Summary | The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487, PubMed:27457814, PubMed:29909994). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:24908487). Plays a role in the regulation of dendritic spine density in hippocampus neurons (PubMed:29909994). Required for normal neurite branching and extension in response to BDNF (PubMed:27457814, PubMed:29909994). Plays a role in BDNF-dependent hippocampal synaptic plasticity (PubMed:29909994, PubMed:27457814). Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814). ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (By similarity). Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes (PubMed:28469074). Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (PubMed:30840898).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MC223772 | Sorcs2 (untagged) - Mouse sortilin-related VPS10 domain containing receptor 2 (Sorcs2), (10ug) |
CNY 14,920.00 |
|
| MG216425 | Sorcs2 (tGFP-tagged) - Mouse sortilin-related VPS10 domain containing receptor 2 (Sorcs2), (10ug) |
CNY 11,210.00 |
|
| MR216425 | Sorcs2 (Myc-DDK-tagged) - Mouse sortilin-related VPS10 domain containing receptor 2 (Sorcs2) |
CNY 8,080.00 |
|
| MR216425L4 | Lenti ORF clone of Sorcs2 (mGFP-tagged) - Mouse sortilin-related VPS10 domain containing receptor 2 (Sorcs2) |
CNY 12,070.00 |
