Sorcs2 (NM_030889) Mouse Untagged Clone
CAT#: MC223772
Sorcs2 (untagged) - Mouse sortilin-related VPS10 domain containing receptor 2 (Sorcs2), (10ug)
CNY 14,920.00
Product images
Specifications
Product Data | |
Type | Mouse Untagged Clone |
Tag | Tag Free |
Synonyms | mKIAA1329; N28137 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MC223772 representing NM_030889
Red=Cloning site Blue=ORF Orange=Stop codon CTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCCGGCGC GCCC ATGGCGCACCGGGGACCCCCGAGCGCCCCGAAGCGTCCTGGCCCTACTGCGCCGGACCGGAGCTTTCAGG CTCTGCTGCCGCCGTGCTGGCCACGTTCGTGGCCGCTGCTGCTGCTGCTGCTGGTGCTGGTGGCTGCCTG CGGAGCGATGGGGCGCTCCCCCCAGCCCGGGCGCCAGGGTCCCGGTGTGCAGATCACTAGGCTGCTGCCC GCGGGACGCACGGAGTCCGGCGATCGCAAAGATCCACAGGCACGAGAATCAGAACCCAGCGTCCCGGGTC TCGGTCCGGGTTCTGCTTCGGGTCCCAGCACCGATGGCGCCCCAGCTCCGGGCAAGGGGCGCAGGGCTCG GGCGGTGCCGGTGGCCGGTGCGGCTTCGGCTTCGCGCGCACAGGTCTCGCTCATCAGCACGTCGTTCGTG CTCAAGGGAGACGCGACGCACAACCAGGCGATGGTACACTGGACAGGAGAGAACAGCAGCGTCATCTTGA TCCTGACAAAGTACTACCATGCAGACATGGGCAAGGTTCTGGAAAGTTCTCTGTGGAGGTCCTCAGATTT TGGGACAACCTACACCAAGCTTACTCTCCAGCCTGGTGTCACCACTGTCATTGACAACTTCTATATCTGC CCAGCTAACAAAAGGAAGATCATCCTGGTGAGCTCATCCCTCGGTGACCGGGAACAGAGCCTCTTCCTCA GCACTGATGAGGGCGCCACGTTCCAGAAGTATCCTGTCCCCTTCCTTGTGGAGATGCTCCTCTTCCACCC GAAGGAGGAGGACAAGGTGCTGGCCTACACCAAGGACAGCAAGCTGTATGTGTCATCGGACCTGGGAAAG AAGTGGACACTTCTGCAGGAACGGGTGACCAAGGACCACGTGTTCTGGGCTGTGTCTGGGGTGGATGACG ACCCAAACTTGGTCCACGTGGAAGCTCAGGACCTCAGTGGAGGCTATCGGTACTACACGTGTCTGATCTA CAACTGCTCAGCCCAGCCACACATAGCACCCTTCTCCGGCCCCATTGACCGCGGGTCCCTGACCGTGCAG GATGAGTACATCTTTTTGAAGGCAACATCAACAAACCGAACCAAGTACTATGTCTCCTATCGCCGAAGTG ACTTTGTCCTGATGAAGCTGCCCAAGTATGCCCTGCCCAAGGACCTACAGATCATCAGCACGGATGAGCA GCAGGTGTTTGTGGCCGTACAGGAGTGGAACCAGGTAGACACCTACAACCTGTACCAGTCAGACCTGCGT GGGGTTCGCTATTCCCTGGTGCTGGAGAATGTGCGCAGCTCGAGGCAAGCCGAGGAGAACGTGGTCATCG ACATCCTTGAGGTCAGAGGGGTGAAGGGAGTCTTCTTGGCAAACCAGAAAGTGGATGGCAAGGTGACCAC AGTCATAACCTACAACAAGGGCCGTGACTGGGATTACCTGAGGCCACCCAGCACCGACATGAATGGGAAG CCCACCAACTGCCAGCCGCCGGACTGTTACCTGCACCTGCACTTGCGGTGGGCAGACAACCCCTATGTGT CAGGCACGGTACACACCAAGGACACTGCCCCTGGTCTCATCATGGGTGCAGGTAACCTGGGCTCACAGCT GGTGGAGTATAAAGAGGAGATGTACATCACATCTGACTGCGGGCACACCTGGAGGCAGGTCTTTGAGGAA GAGCACCATGTGTTGTACCTGGACCACGGTGGTGTCATTGCCGCCATCAAGGACACCTCCATCCCCCTGA AGATCCTCAAGTTCAGCGTGGATGAGGGCCACACGTGGAGCACACACAACTTCACCAGCACCTCAGTGTT CGTGGATGGGTTGCTGAGCGAGCCAGGGGATGAGACGCTGGTCATGACGGTCTTTGGTCACATCAGCTTC CGCTCTGACTGGGAGCTGGTCAAGGTTGACTTCCGGCCCTCCTTCCCCCGGCAGTGTGGCGAGGATGACT ACAGCTCCTGGGACCTCACTGACCTCCAGGGTGATCACTGCATCATGGGCCAACAGAGAAGTTACCGGAA GAGAAAGTCCACATCCTGGTGTGTCAAGGGACGGAGCTTCACATCAGCACTCACGTCACGTGTGTGCAAG TGCCGGGACTCCGACTTCCTCTGTGACTACGGGTTTGAGCGCTCATCTTCCTCGGAGTCCACTGCCAACA AGTGCTCTGCCAACTTCTGGTTCAACCCTTTGTCTCCTCCTGAAGACTGTGTCTTGGGTCAGACTTACAC TAGTAGCCTTGGGTACCGGAAGGTGGTGTCCAATGTGTGTGAAGGTGGTGTGGACCTGCAGCAGAGCCCA GTGCAGCTGCAGTGCCCCCTCCAGGCACCCCGGGGCCTGCAGGTGAGCATCCGAGGAGAGGCAGTGGCCG TGCGGCCTAGAGAAGATGTGCTGTTTGTGGTGCGACAGGAACAGGGTGATGTCCTGACCACTAAATATCA GGTGGATCTTGGGGATGGCTTCAAGGCCATGTACGTGAACCTCACTCTGACAGGCGAGCCCATTCGACAT CACTATGAGAGTCCTGGCATCTACCGAGTGTCCGTCAGGGCTGAGAACATGGCAGGCCATGATGAGGCTG TGCTCTTTGTCCAGGTCAACTCTCCCCTGCAGGCCCTCTACCTCGAGGTAGTTCCTGTCATTGGCGTCAA CCAGGAGGTGAACCTCACAGCCGTGCTGTTACCCCTGAATCCCAACCTCACTGTCTTCTACTGGTGGATC GGCCACAGCTTGCAGCCTCTGCTTTCCTTGGACAACTCGGTGACAACAAAGTTTACGGACGCTGGGGATG TGCGTGTGACAGTGCAAGCTGCCTGCGGGAACTCAGTGCTTCAGGACTCCAGGCTCGTCCGTGTGCTCGA TCAGTTCCAGGTGGTGCCTCTGCGGTTCTCCAGGGAGCTGGACACCTTTAACCCCAACACTCCTGAATGG AGGGAAGATGTGGGACTGGTGGTCACCCGACTGCTCTCCAAGGAGACCAGCATCCCAGAGGAGCTGCTTG TGACTGTGGTAAAGCCAGGGCTGCCCACCATAGCCGACTTGTATGTGCTTCTGCCTCTGCCAAGGCCCAC AAGGAAGAGGAGCCTCACAAGTGACAAGAGACTGGCAGCCGTGCAGCAGGCGCTGAACTCTCATAGAATC AGCTTCATCCTTCGAGGAGGGCTTCGTATCCTGGTGGAGCTGAGGGACACAGACACAGGTCCTCAGAGGC CAGGTGGCAGTGGTGGCTACTGGGCCGTGGTGGTCCTCTTTGTCATTGGGCTCTTTGCAGTAGGAGCATT CATCCTCTACAAGTTCAAAAGGAAACGTCCAGGCAGGACAGTGTACGCCCAGATGCACAATGAGAAGGAA CAGGAGATGACAAGTCCCGTGAGTCACAGTGAGGATGCCCAGAGCACCATGCAGGGCAACCACTCAGGGG TGGTCCTGAGCATCAACTCTCGTGAGATGCATAGCTACCTGGTGGGCTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
Restriction Sites | AscI-MluI |
ACCN | NM_030889 |
Insert Size | 3480 bp |
OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_030889.2, NP_112151.2 |
RefSeq Size | 5722 bp |
RefSeq ORF | 3480 bp |
Locus ID | 81840 |
UniProt ID | Q9EPR5 |
Gene Summary | The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487, PubMed:27457814, PubMed:29909994). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:24908487). Plays a role in the regulation of dendritic spine density in hippocampus neurons (PubMed:29909994). Required for normal neurite branching and extension in response to BDNF (PubMed:27457814, PubMed:29909994). Plays a role in BDNF-dependent hippocampal synaptic plasticity (PubMed:29909994, PubMed:27457814). Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814). ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (By similarity). Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes (PubMed:28469074). Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (PubMed:30840898).[UniProtKB/Swiss-Prot Function] |
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MG216425 | Sorcs2 (tGFP-tagged) - Mouse sortilin-related VPS10 domain containing receptor 2 (Sorcs2), (10ug) |
CNY 11,210.00 |
|
MR216425 | Sorcs2 (Myc-DDK-tagged) - Mouse sortilin-related VPS10 domain containing receptor 2 (Sorcs2) |
CNY 8,080.00 |
|
MR216425L3 | Lenti ORF clone of Sorcs2 (Myc-DDK-tagged) - Mouse sortilin-related VPS10 domain containing receptor 2 (Sorcs2) |
CNY 12,070.00 |
|
MR216425L4 | Lenti ORF clone of Sorcs2 (mGFP-tagged) - Mouse sortilin-related VPS10 domain containing receptor 2 (Sorcs2) |
CNY 12,070.00 |