Mlh1 (NM_026810) Mouse Tagged ORF Clone
CAT#: MR210511
- TrueORF®
Mlh1 (Myc-DDK-tagged) - Mouse mutL homolog 1 (E. coli) (Mlh1)
ORF Plasmid: tGFP
"NM_026810" in other vectors (4)
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CNY 5,576.00
CNY 6,650.00
Cited in 5 publications. |
CNY 300.00
Specifications
Product Data | |
Type | Mouse Tagged ORF Clone |
Tag | Myc-DDK |
Synonyms | 1110035C23Rik; AI317206; AI325952; AI561766 |
Vector | pCMV6-Entry |
E. coli Selection | Kanamycin (25 ug/mL) |
Mammalian Cell Selection | Neomycin |
Sequence Data |
>MR210511 ORF sequence
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCGTTTGTAGCAGGAGTTATTCGGCGTCTGGACGAGACGGTGGTGAACCGCATAGCGGCGGGGGAAG TCATTCAGCGGCCGGCCAATGCTATCAAAGAGATGATAGAAAACTGTTTAGATGCAAAATCTACAAATAT TCAAGTGGTTGTTAAGGAAGGTGGCCTGAAGCTAATTCAGATCCAAGACAATGGCACTGGAATCAGGAAG GAAGATCTGGATATTGTGTGTGAGAGGTTCACTACGAGTAAACTGCAGACTTTTGAGGATTTAGCCAGTA TTTCTACCTATGGCTTTCGTGGTGAGGCATTGGCAAGCATAAGCCATGTGGCCCATGTCACTATTACAAC CAAAACAGCTGATGGGAAATGTGCGTACAGAGCAAGTTACTCAGATGGAAAGCTGCAAGCCCCTCCTAAA CCCTGTGCAGGCAACCAGGGCACCCTGATCACGGTGGAAGACCTTTTTTACAACATAATCACAAGGAGGA AAGCTTTAAAAAATCCAAGTGAAGAGTACGGAAAAATTTTGGAAGTTGTTGGCAGGTATTCAATACACAA TTCAGGCATTAGTATCTCAGTTAAAAAACAAGGTGAGACAGTATCTGATGTCAGAACACTGCCCAATGCC ACAACCGTGGACAACATTCGCTCCATCTTTGGAAATGCGGTTAGTCGAGAACTGATAGAAGTTGGGTGTG AGGATAAAACCCTAGCTTTCAAAATGAATGGCTATATATCGAATGCAAACTATTCAGTGAAGAAGTGCAT TTTCCTACTCTTCATCAACCACCGTCTGGTAGAATCAGCTGCCTTGAGAAAAGCCATTGAAACTGTATAT GCAGCATATTTGCCCAAAAACACACACCCATTCCTGTACCTCAGTTTGGAAATCAGCCCTCAGAACGTGG ACGTCAATGTACACCCCACCAAGCACGAAGTTCACTTTCTGCATGAGGAGAGCATTCTGCAGCGTGTGCA GCAGCACATTGAGAGCAAGCTGCTGGGCTCCAATTCCTCCAGGATGTATTTCACCCAGACCTTGCTTCCA GGACTTGCTGGGCCCTCTGGGGAGGCAGCTAGACCCACGACAGGGGTGGCTTCCTCATCCACTAGTGGAA GTGGCGACAAGGTCTACGCTTACCAGATGGTCCGTACGGACTCCCGGGATCAGAAGCTTGACGCCTTTCT GCAGCCTGTAAGCAGCCTTGTGCCCAGCCAGCCCCAGGACCCTGCCCCTGTCCGAGGGGCCAGGACAGAG GGCTCTCCTGAAAGGGCCACGCGGGAGGATGAGGAGATGCTTGCTCTCCCAGCCCCCGCTGAAGCAGCTG CTGAGAGTGAGAACTTGGAGAGGGAATCACTAATGGAGACTTCAGACACAGCCCAGAAAGCGGCACCCAC TTCCAGTCCAGGAAGCTCCAGAAAGAGACATCGGGAGGACTCTGATGTGGAAATGGTGGAAAATGCTTCC GGGAAGGAAATGACAGCTGCTTGCTACCCCAGGAGGAGGATCATTAACCTCACCAGCGTCTTGAGTCTCC AGGAAGAGATTAGTGAGCGGTGCCATGAGACTCTCCGGGAGATGCTCCGTAACCATTCCTTTGTGGGCTG TGTGAATCCTCAGTGGGCCTTGGCACAGCACCAGACCAAGCTATACCTCCTCAACACTACCAAGCTCAGT GAAGAGCTGTTCTACCAGATACTCATTTATGATTTTGCCAACTTTGGTGTTCTGAGGTTATCGGAACCAG CGCCACTCTTCGACCTGGCCATGCTGGCCTTAGACAGTCCTGAAAGTGGCTGGACAGAGGACGACGGCCC GAAGGAAGGGCTTGCAGAGTACATTGTCGAGTTTCTGAAGAAGAAAGCGGAGATGCTTGCAGACTATTTC TCTGTGGAGATCGATGAGGAAGGGAACCTGATCGGATTACCTCTTCTGATTGACAGCTATGTGCCACCTT TGGAGGGACTGCCTATCTTCATTCTTCGACTGGCCACTGAGGTGAATTGGGATGAAGAAAAGGAGTGTTT TGAAAGTCTCAGTAAAGAATGTGCTATGTTTTACTCCATTCGGAAGCAGTATATACTGGAGGAGTCGACC CTCTCAGGCCAGCAGAGTGACATGCCTGGCTCCACGTCAAAGCCCTGGAAGTGGACTGTGGAGCACATTA TCTATAAAGCCTTCCGCTCACACCTCCTACCTCCGAAGCATTTCACAGAAGATGGCAATGTCCTGCAGCT TGCCAACCTGCCAGATCTATACAAAGTCTTTGAGCGGTGT ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >MR210511 protein sequence
Red=Cloning site Green=Tags(s) MAFVAGVIRRLDETVVNRIAAGEVIQRPANAIKEMIENCLDAKSTNIQVVVKEGGLKLIQIQDNGTGIRK EDLDIVCERFTTSKLQTFEDLASISTYGFRGEALASISHVAHVTITTKTADGKCAYRASYSDGKLQAPPK PCAGNQGTLITVEDLFYNIITRRKALKNPSEEYGKILEVVGRYSIHNSGISISVKKQGETVSDVRTLPNA TTVDNIRSIFGNAVSRELIEVGCEDKTLAFKMNGYISNANYSVKKCIFLLFINHRLVESAALRKAIETVY AAYLPKNTHPFLYLSLEISPQNVDVNVHPTKHEVHFLHEESILQRVQQHIESKLLGSNSSRMYFTQTLLP GLAGPSGEAARPTTGVASSSTSGSGDKVYAYQMVRTDSRDQKLDAFLQPVSSLVPSQPQDPAPVRGARTE GSPERATREDEEMLALPAPAEAAAESENLERESLMETSDTAQKAAPTSSPGSSRKRHREDSDVEMVENAS GKEMTAACYPRRRIINLTSVLSLQEEISERCHETLREMLRNHSFVGCVNPQWALAQHQTKLYLLNTTKLS EELFYQILIYDFANFGVLRLSEPAPLFDLAMLALDSPESGWTEDDGPKEGLAEYIVEFLKKKAEMLADYF SVEIDEEGNLIGLPLLIDSYVPPLEGLPIFILRLATEVNWDEEKECFESLSKECAMFYSIRKQYILEEST LSGQQSDMPGSTSKPWKWTVEHIIYKAFRSHLLPPKHFTEDGNVLQLANLPDLYKVFERC TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Restriction Sites | SgfI-MluI Cloning Scheme for this gene Plasmid Map |
ACCN | NM_026810 |
ORF Size | 2283 bp |
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
Reference Data | |
RefSeq | NM_026810.1, NP_081086.1 |
RefSeq Size | 2598 bp |
RefSeq ORF | 2283 bp |
Locus ID | 17350 |
UniProt ID | Q9JK91 |
MW | 84.7 kDa |
Gene Summary | Heterodimerizes with Pms2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (Msh2-Msh6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of Pms2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (Mlh1-Pms2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with Mlh3 to form MutL gamma which plays a role in meiosis (By similarity).[UniProtKB/Swiss-Prot Function] |
Citations (5)
The use of this cDNA Clones has been cited in the following citations: |
---|
MLH1 Deficiency-Triggered DNA Hyper-Excision by Exonuclease 1 Activates the cGAS-STING Pathway
,null,
Cancer cell
,PubMed ID 33338427
[Mlh1]
|
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway.
,null,
Cancer cell
,PubMed ID 33338427
[Mlh1]
|
MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
,Guan, J;Lu, C;Jin, Q;Lu, H;Chen, X;Tian, L;Zhang, Y;Ortega, J;Zhang, J;Siteni, S;Chen, M;Gu, L;Shay, JW;Davis, AJ;Chen, ZJ;Fu, YX;Li, GM;,
Cancer cell
,PubMed ID 33338427
[MLH1]
|
DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity
,Lu, C;Guan, J;Lu, S;Jin, Q;Rousseau, B;Lu, T;Stephens, D;Zhang, H;Zhu, J;Yang, M;Ren, Z;Liang, Y;Liu, Z;Han, C;Liu, L;Cao, X;Zhang, A;Qiao, J;Batten, K;Chen, M;Castrillon, DH;Wang, T;Li, B;Diaz, LA;Li, GM;Fu, YX;,
Cancer cell
,PubMed ID 33338425
[MLH1]
|
Pathological prognostic factors of pseudomyxoma peritonei: comprehensive clinicopathological analysis of 155 cases.
,null,
Human pathology
,PubMed ID 31926211
[Mlh1]
|
Documents
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Resources
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
MC221356 | Mlh1 (untagged) - Mouse mutL homolog 1 (E. coli) (Mlh1), (10ug) |
CNY 9,790.00 |
|
MG210511 | Mlh1 (tGFP-tagged) - Mouse mutL homolog 1 (E. coli) (Mlh1) |
CNY 7,320.00 |
|
MR210511L3 | Lenti ORF clone of Mlh1 (Myc-DDK-tagged) - Mouse mutL homolog 1 (E. coli) (Mlh1) |
CNY 8,550.00 |
|
MR210511L4 | Lenti ORF clone of Mlh1 (mGFP-tagged) - Mouse mutL homolog 1 (E. coli) (Mlh1) |
CNY 7,976.00 |