United States
Germany
Japan
United Kingdom
China
Slc8a3 (NM_080440) Mouse Untagged Clone
CAT＃: MC222653
Slc8a3 (untagged) - Mouse solute carrier family 8 (sodium/calcium exchanger), member 3 (Slc8a3), transcript variant 2, (10ug)
CNY 11,880.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | AW742262; Ncx3 |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC222653 representing NM_080440
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCGTGGTTACGGCTGCAGCCTCTCACCTCTGCCTTCCTCCATTTTGGGCTGGTTACTTTTGTGCTCT TCCTGAATTGTCTTCGAGCAGAGGCTGGTGACTCGGGGGATGTGCCCAGTGCAGGGCAGAACAATGAGTC CTGTTCGGGGTCATCAGACTGCAAGGAGGGTGTCATTTTGCCAATCTGGTATCCAGAGAACCCTTCCCTT GGGGACAAGATTGCCAGGGTCATTGTCTATTTTGTGGCCCTGATATACATGTTTCTTGGGGTGTCTATCA TTGCTGACCGATTCATGGCATCTATTGAAGTCATTACTTCCCAAGAGAGGGAAGTGACCATCAAGAAGCC CAATGGAGAGACCAGCACAACTACAATTCGGGTATGGAATGAAACTGTCTCCAATCTGACCCTGATGGCC CTGGGCTCTTCTGCTCCAGAGATTCTCCTGTCTTTAATTGAGGTGTGTGGTCACGGGTTCATTGCTGGTG ATCTGGGACCATCTACCATCGTTGGCAGTGCAGCCTTCAACATGTTCATCATCATTGGCATCTGTGTCTA TGTGATCCCAGATGGGGAGACTCGAAAGATCAAGCACCTGCGAGTCTTCTTCGTCACGGCTGCTTGGAGC ATCTTCGCCTACATTTGGCTCTATATGATCCTGGCAGTCTTCTCTCCTGGTGTGGTCCAGGTTTGGGAAG GCCTCCTTACTCTCTTCTTCTTTCCCGTGTGTGTCCTGCTGGCTTGGGTGGCAGATAAGCGACTGCTCTT CTACAAATACATGCACAAAAAATACCGCACAGATAAACACCGAGGAATTATCATTGAGACAGAGGGTGAC CACCCTAAGGGCATTGAGATGGATGGGAAAATGATGAATTCTCACTTTCTAGATGGGAACTTTACACCTT TGGAAGGAAAGGAGGTAGATGAATCTCGCAGGGAAATGATCCGGATTCTAAAGGATCTGAAACAAAAACA CCCAGAAAAGGACCTAGATCAGCTGGTGGAGATGGCCAATTACTATGCTCTTTCCCATCAACAGAAGAGC CGTGCTTTCTACCGCATCCAAGCCACCCGGATGATGACTGGTGCGGGCAATATACTTAAGAAGCATGCAG CCGAGCAAGCCAAGAAGACCTCCAGCATGAGCGAGGTGCATACCGATGAGCCGGAGGACTTTGCCTCTAA GGTCTTCTTTGACCCATGTTCTTATCAGTGCCTGGAGAACTGTGGAGCTGTCCTCCTGACCGTGGTGAGG AAAGGGGGAGATATATCCAAGACCATGTACGTGGACTACAAAACAGAGGACGGCTCCGCCAATGCAGGGG CAGACTATGAGTTCACAGAGGGCACTGTGGTTCTGAAGCCAGGAGAGACCCAGAAGGAGTTCTCTGTGGG CATCATTGATGATGACATTTTTGAGGAGGATGAACACTTCTTTGTGAGGCTGAGCAATGTCCGTGTAGAA GAGGAGCAGCTGGCGGAGGGGATGCTCCCAGCAATACTCAATAGTCTTCCTTTGCCTCGGGCTGTCCTGG CCTCCCCTTGTGTGGCCACAGTAACCATCTTGGATGATGACCATGCAGGAATTTTCACTTTTGAATGTGA TACCATTCATGTCAGTGAAAGTATTGGTGTTATGGAAGTCAAGGTTTTGAGGACATCAGGTGCCAGGGGC ACAGTCATCGTCCCTTTTAGGACAGTAGAAGGGACAGCCAAGGGTGGTGGCGAGGACTTTGAAGATGCAT ATGGGGAGCTGGAGTTCAAGAATGATGAAACAGTCAAAACAATTCACATCAAGGTAATTGATGATAAGGC GTATGAGAAAAACAAGAATTACGTCATTGAGATGATGGGCCCCCGCATGGTGGATATGAGTGTTCAGAAA GCGCTCCTGTTATCTCCAGAAGTGACAGACAGGAAGCTGACTGTGGAGGAAGAGGAAGCCAAGAGAATAG CAGAGATGGGAAAGCCAGTATTGGGTGAACACCCCAAACTAGAGGTCATCATTGAAGAGTCCTATGAGTT CAAGAGTACAGTGGATAAGCTGATCAAGAAGACAAACCTGGCATTGGTTGTGGGGACCCATTCCTGGAGG GACCAGTTCATGGAAGCCATCACTGTTAGTGCAGGAGGGGATGAGGATGAAGACGAATCTGGAGAGGAGA GGCTGCCATCCTGCTTTGACTACGTCATGCACTTCCTGACGGTCTTCTGGAAGGTGCTCTTTGCCTGTGT GCCCCCCACAGAGTACTGCCACGGCTGGGCCTGCTTCGTGGTCTCCATCCTCATTATTGGCATGCTCACC GCCATCATCGGGGACCTGGCCTCTCACTTCGGCTGCACCATCGGGCTCAAGGATTCGGTCACAGCTGTTG TTTTTGTGGCATTCGGCACCTCTGTGCCAGATACATTTGCCAGCAAAGCCGCTGCCCTGCAGGACGTGTA TGCAGATGCTTCCATTGGCAACGTCACAGGCAGTAATGCCGTCAATGTCTTCCTGGGTATTGGTTTGGCC TGGTCCGTGGCCGCCATCTACTGGGCCATGCAGGGACAGGAGTTCCATGTGTCCGCTGGCACTCTGGCCT TCTCGGTCACTCTTTTCACCATCTTTGCATTTGTCTGCCTCAGTGTGCTCTTGTATCGTCGGCGGCCCCA TCTGGGCGGGGAGCTCGGAGGTCCTCGTGGCTGCAAGCTTGCCACGACATGGCTCTTTGTGAGCCTATGG CTCCTCTACATACTATTTGCCACGCTGGAGGCCTACTGCTACATCAAGGGGTTCTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_080440 |
| Insert Size | 2787 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_080440.3, NP_536688.2 |
| RefSeq Size | 4964 bp |
| RefSeq ORF | 2787 bp |
| Locus ID | 110893 |
| UniProt ID | S4R2P9 |
| Gene Summary | Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain (PubMed:14722618, PubMed:21593315). In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:14722618, PubMed:21593315). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:14722618). In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (PubMed:21593315). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (PubMed:24616101). Isoform 1 displays higher calcium exchanger activity than isoform 2, probably because isoform 1 has a lower threshold for activation by cytoplasmic Ca(2+) (PubMed:24616101).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (2) contains 2 alternate in-frame coding exons compared to variant 1. This results in a slightly longer isoform (2) containing two protein segments not found in isoform 1. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG221680 | Slc8a3 (tGFP-tagged) - Mouse solute carrier family 8 (sodium/calcium exchanger) member 3 (Slc8a3) transcript variant 2, (10ug) |
CNY 7,890.00 |
|
| MR221680 | Slc8a3 (Myc-DDK-tagged) - Mouse solute carrier family 8 (sodium/calcium exchanger), member 3 (Slc8a3), transcript variant 2 |
CNY 6,800.00 |
|
| MR221680L3 | Lenti ORF clone of Slc8a3 (Myc-DDK-tagged) - Mouse solute carrier family 8 (sodium/calcium exchanger), member 3 (Slc8a3), transcript variant 2 |
CNY 9,030.00 |
|
| MR221680L4 | Lenti ORF clone of Slc8a3 (mGFP-tagged) - Mouse solute carrier family 8 (sodium/calcium exchanger), member 3 (Slc8a3), transcript variant 2 |
CNY 9,030.00 |
