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Slc8a3 (NM_080440) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR221680L3V
- LentiORF®
-
Lenti ORF particles, Slc8a3 (Myc-DDK-tagged) - Mouse solute carrier family 8 (sodium/calcium exchanger), member 3 (Slc8a3), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 14,345.00
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Specifications
| Product Data | |
| Product Name | Slc8a3 (NM_080440) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AW742262; Ncx3 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_080440 |
| ORF Size | 2784 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR221680).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_080440.3, NP_536688.2 |
| RefSeq Size | 4964 bp |
| RefSeq ORF | 2787 bp |
| Locus ID | 110893 |
| Gene Summary | Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain (PubMed:14722618, PubMed:21593315). In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:14722618, PubMed:21593315). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:14722618). In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (PubMed:21593315). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (PubMed:24616101). Isoform 1 displays higher calcium exchanger activity than isoform 2, probably because isoform 1 has a lower threshold for activation by cytoplasmic Ca(2+) (PubMed:24616101).[UniProtKB/Swiss-Prot Function] |
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