United States
Germany
Japan
United Kingdom
China
Ddb2 (NM_028119) Mouse Untagged Clone
CAT＃: MC212159
Ddb2 (untagged) - Mouse damage specific DNA binding protein 2 (Ddb2), (10ug)
CNY 3,990.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | 2610043A19Rik |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC212159 representing NM_028119
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCTCCCAAGAAATGCCCAGAAACCCAGAAGTCCCCCGACGTTGCGGTGCTCCTCAGGAGCAAAAGTC GCAGAGGTCCTCAGGAGCTGGAGCCCGAAGCCAAGAAGCTGCGTGTGCAGGGTCCCGTTTCTAGCAGGAC ATGTGAGTCGTGCTGCCTTCTGGCAGAGTTGTCCAGCCTGCAGATCCCTTCACGGAGTAGCAGCATTGTC AGGGATCTTTACCAGCATAAGTTGGGCAAAGCCACCTGGTCATCACTACAGCAGGGTCTGCAGAAGTCCT TTTTGCACTCTCTAGCTTCTTACCAGGTATTCCGAAAAGCTGCCCCCTTTGACAGGAGGACTACGTCCTT GGCATGGCACCCGACTCATCCCAGTACCCTGGCTGTGGGCTCCAAAGGGGGAGATATTATGATCTGGAAC TTTGGCATCAAGGACAAACCTATCTTCCTTAAAGGGATTGGAGCTGGAGGAAGCATCACTGGGCTGAAGT TTAACCATCTCAATACCAACCAGTTTTTTGCCTCCTCAATGGAGGGAACAACCAGGCTGCAGGATTTTAA AGGCAACATTCTCAGAGTTTATACCAGCTCAAACTCTTGCAAGGTCTGGTTTTGCAGCCTTGATGTTTCT GCCAAGAGCAGAGTGGTGGTTACAGGAGACAATATGGGACATGTGATCCTGTTGAGCACAGATGGCAAGG AGCTTTGGAACCTCCGAATGCACAAGAAGAAAGTAGCCCACGTGGCCCTGAATCCCTGCTGTGATTGGCT TCTGGCCACAGCCTCCATAGATCAAACAGTGAAGATTTGGGACCTGCGCCAAATTAAAGGGAAAGACAGC TTCCTCTACTCACTGCCTCACAGGCATCCTGTCAATGCAGCTTGTTTTAGCCCAGATGGAGCTCGGCTCC TGACTACTGACCAGAACAATGAGATTCGGGTTTACTCTGCCTCCCAGTGGGATAGCCCCCTGAATCTGAT CTCCCACCCTCACCGCCATTTTCAGCACCTCACACCCATCAAGGCGACCTGGCATTCACGGCACAACCTC ATTGTTGTGGGCCGATACCCAGATCCTAATCTTAAAAGTTGTGTTCCCTATGAACTAAGGACAATAGATG TGTTTGATGGAAGCTCAGGGAAGATGATGTGTCAGCTCTATGATCCAGGATACTCCGGTATTACTTCGCT CAATGAGTTCAATCCTATGGGAGACACACTGGCCTCTACTATGGGTTATCATATTCTCATTTGGAGCCAA GAGGAAGATGGGTCACAGAAAGATCATGAAAGACTATGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_028119 |
| Insert Size | 1299 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_028119.5, NP_082395.2 |
| RefSeq Size | 1929 bp |
| RefSeq ORF | 1299 bp |
| Locus ID | 107986 |
| UniProt ID | Q99J79 |
| Gene Summary | Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER.[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG225146 | Ddb2 (tGFP-tagged) - Mouse damage specific DNA binding protein 2 (Ddb2), (10ug) |
CNY 3,710.00 |
|
| MR225146 | Ddb2 (Myc-DDK-tagged) - Mouse damage specific DNA binding protein 2 (Ddb2) |
CNY 3,330.00 |
|
| MR225146L3 | Lenti ORF clone of Ddb2 (Myc-DDK-tagged) - Mouse damage specific DNA binding protein 2 (Ddb2) |
CNY 5,230.00 |
|
| MR225146L4 | Lenti ORF clone of Ddb2 (mGFP-tagged) - Mouse damage specific DNA binding protein 2 (Ddb2) |
CNY 5,230.00 |
