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Micu1 (NM_144822) Mouse Untagged Clone
CAT＃: MC201052
Micu1 (untagged) - Mouse calcium binding atopy-related autoantigen 1 (Cbara1), nuclear gene encoding mitochondrial protein, (10ug)
CNY 3,656.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | C730016L05Rik; Calc; Cbara1 |
| Vector | PCMV6-Kan/Neo |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>BC018320 sequence for NM_144822
CGTCTCTATGGTTGTCAGAGGTGGGCGGCATTCTCCGAGTTGCTGCTAAAGCTGGAGCGCGGACGGGATG TTTCGTCTTAACACCCTTTCTGCGTTGGCAGAACTAGCTGTGGGCTCTCGCTGGTACCATGGGGCATCAC AGCCCACACAGACCAAACGAAGATTGATGCTGGTGGCGTTCCTGGGAGCATCTGCAGTGACTGCAAGTAC CGGTCTCCTGTGGAAGAAGGCTCACGCAGAATCTCCACCATGCGTTAACAGCAAGAAGCCTGACACAGAA GATAAAGAGAGAAACAAAGACAGCGGGGAAGTGTCCAGCCGTGAAGGAAGGGCTGCAGATGCTGCGGCAG AGCCTTATCCTGAGGACAAGAAGAAGAAGCGCTCTGGATTCAGAGACAGAAAAGTGATGGAGTATGAGAA TCGAATCCGAGCCTACTCCACACCAGACAAAATTTTCCGATATTTTGCCACCTTGAAAGTAATCAACGAA CCTGGTGAAACCGAAGTGTTCATGACTCCGCAGGACTTTGTGCGCTCCATAACGCCCAATGAGAAGCAGC CAGAACACTTGGGCCTGGATCAGTATATAATAAAGCGCTTTGATGGAAAGAAAATTGCCCAGGAACGAGA AAAATTTGCTGATGAAGGCAGCATCTTCTACAGCCTTGGAGAGTGTGGGCTCATCTCCTTCTCTGACTAC ATCTTCCTCACAACAGTCCTCTCCACTCCTCAGAGAAATTTTGAAATTGCTTTCAAGATGTTTGACTTGA ATGGAGACGGAGAGGTAGACATGGAGGAGTTTGAGCAGGTTCAGAGCATCATTCGCTCCCAGACCAGCAT GGGCATGCGTCACAGAGACCGTCCAACCACTGGGAACACCCTCAAGTCTGGCTTATGTTCGGCCCTCACG ACCTACTTTTTTGGAGCTGATCTCAAAGGGAAACTGACCATCAAAAACTTCCTGGAATTTCAGCGCAAAC TTCAGCATGACGTTCTAAAGCTGGAGTTTGAACGCCATGACCCGGTAGATGGGAGAATCTCTGAGAGGCA GTTCGGGGGCATGCTGCTGGCCTACAGTGGAGTGCAGTCCAAGAAGCTGACCGCCATGCAGAGACAGCTG AAGAAGCACTTCAAAGATGGGAAGGGCCTGACTTTCCAGGAGGTAGAGAACTTCTTCACTTTCCTGAAGA ACATTAATGACGTGGACACTGCACTAAGCTTTTACCACATGGCTGGAGCATCTCTTGATAAAGTGACCAT GCAGCAAGTGGCCAGGACAGTGGCGAAGGTCGAACTCTCGGACCATGTGTGTGACGTGGTGTTCGCGCTC TTTGACTGTGATGGCAATGGGGAGCTGAGCAACAAGGAGTTCGTTTCCATCATGAAGCAGCGGCTGATGA GAGGCCTGGAGAAGCCCAAGGACATGGGCTTCACCCGCCTCATGCAGGCCATGTGGAAATGTGCCCAAGA AACTGCCTGGGACTTTGCTCTGCCCAAATAGTATTCCCACCTCCTGCACCTTAGCACCCTGCAAGCCCTG GAGTGGCCCTTCATGCTGCTGATGCATCGGGAGTGGTGCCCACCTCCCCATCTTTCTGGGAGTAACCTCT GGGCTCAGCCGGCTTCCCTCTCCACCCTGCCCTGACCCCATCAGTGTTCTGCTAGGCTCTGAGTCTGCAG TCGGATGGAAGGTCCTAAAACAGGACTGAGGCTTCAAAGTAGAGACCTTAGTTAACTCCCTTAGCAAGTG CCCTGTGGGTCAGTGCAGGAGCCCTCCCAACCCCGGCCAGCCCGGGAGGGAGGCAGCTCTGCTCTGCTCT GACATCTGTCTCTCGCTGTGGATTTATAGTAGCAAGAACACTCCCTGCCATTTTCCTCCTGCTGTTTTTA AGCTGCAAGTTTGGAAATGAGCTGGCAGGCGAAAGGAAGTGTGATGAATGATAATGCAGATGACCCTGGC ACCCTGAGCTGGCAGGAAGCCTGGCCAGAGGAGGGTCTGTGTTAGCCACCAGGGGCTCCAGGAAGGCACT GTGCCCCCAGCAGAATCCAGATTCCAAGTGGCTGCTTTAAGCAGCTCTCCAGAACTTCCCAGCTCTGTGG TTTCCTCCCAGGCTCCCTGCGATGCCTCCTCTGGGACTCTGCTTCACTAGAGCAATGGCTGAGCCCCTGT CCCTGTGTCTCATCCCCTCTCTATGGACCTGTGGAGCCCAGACCCAGCTCAGAGCCTAGCTGCCCTCTGT CTAAGACACTCGTAAAATATCACTTTAATTATAGCACTTTGCAGGAAATACCCGCAAAAAAAAAAAAAAA AAAAAAAAAAA |
| Restriction Sites | RsrII-NotI |
| ACCN | NM_144822 |
| Insert Size | 1434 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | BC018320, AAH18320 |
| RefSeq Size | 2321 bp |
| RefSeq ORF | 1434 bp |
| Locus ID | 216001 |
| UniProt ID | Q8VCX5 |
| Gene Summary | Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:24560927). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium (PubMed:24560927). MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (By similarity). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (By similarity). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (By similarity). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (By similarity).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (3) lacks two alternate exons in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG207652 | Micu1 (tGFP-tagged) - Mouse calcium binding atopy-related autoantigen 1 (Cbara1) |
CNY 5,256.00 |
|
| MR207652 | Micu1 (Myc-DDK-tagged) - Mouse calcium binding atopy-related autoantigen 1 (Cbara1), nuclear gene encoding mitochondrial protein |
CNY 3,656.00 |
|
| MR207652L3 | Lenti ORF clone of Micu1 (Myc-DDK-tagged) - Mouse calcium binding atopy-related autoantigen 1 (Cbara1), nuclear gene encoding mitochondrial protein |
CNY 5,230.00 |
|
| MR207652L4 | Lenti ORF clone of Micu1 (mGFP-tagged) - Mouse calcium binding atopy-related autoantigen 1 (Cbara1), nuclear gene encoding mitochondrial protein |
CNY 5,230.00 |
