Topoisomerase II alpha (TOP2A) Mouse Monoclonal Antibody [Clone ID: UMAB146]
CAT#: UM870043
TOP2A mouse monoclonal antibody,clone UMAB146
Size: 100 ul
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CNY 1,150.00
Cited in 1 publication. |
CNY 4,840.00
CNY 300.00
CNY 1,430.00
Specifications
Product Data | |
Clone Name | UMAB146 |
Applications | IHC, WB |
Recommend Dilution | WB 1:200, IHC 1:200 |
Reactivity | Human, Mouse, Rat |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Human recombinant protein fragment corresponding to amino acids 1100-1531 of human TOP2A(NP_001058) produced in E.coli. |
Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 0.5~1.0 mg/ml (Lot Dependent) |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | DNA topoisomerase II alpha |
Database Link | |
Background | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul |
Synonyms | TOP2; TOP2alpha; TOPIIA; TP2A |
Reference Data | |
Protein Families | Druggable Genome |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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Type IIB DNA topoisomerase is downregulated by trastuzumab and doxorubicin to synergize cardiotoxicity
,Jiang, J;Mohan, N;Endo, Y;Shen, Y;Wu, WJ;,
Oncotarget
,PubMed ID 29464058
[TOP2A]
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抗体相关资料 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
UM800043 | TOP2A mouse monoclonal antibody,clone UMAB146 |
CNY 2,999.00 |
|
UM800043CF | Carrier-free (BSA/glycerol-free) TOP2A mouse monoclonal antibody,clone UMAB146 |
CNY 4,999.00 |
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