MYBPC3 Mouse Monoclonal Antibody [Clone ID: OTI2E7]

Specifications

Product Data
Clone Name	OTI2E7
Applications	ELISA
Recommend Dilution	ELISA 1:5000-10000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human MYBPC3（C0-C1） (NP_000247) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Predicted Protein Size	140.8 kDa
Gene Name	myosin binding protein C, cardiac
Database Link	NP_000247 Entrez Gene 4607 Human UniProt ID Q14896
Background	MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Synonyms	CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

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