MYBPC3 Mouse Monoclonal Antibody [Clone ID: OTI2E7]

Specifications

Product Data
Clone Name	OTI2E7
Applications	ELISA
Recommend Dilution	ELISA 1:5000-10000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human MYBPC3（C0-C1） (NP_000247) produced in E.coli.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Predicted Protein Size	140.8 kDa
Gene Name	myosin binding protein C3
Database Link	NP_000247 Entrez Gene 4607 Human UniProt ID Q14896
Background	MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Synonyms	CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

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