TBLR1 (TBL1XR1) Mouse Monoclonal Antibody [Clone ID: OTI2A8]

Specifications

Product Data
Clone Name	OTI2A8
Applications	WB
Recommend Dilution	WB 1:500~2000
Reactivity	Human, Rat, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human TBL1XR1 (NP_078941) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	55.4 kDa
Gene Name	transducin (beta)-like 1 X-linked receptor 1
Database Link	NP_078941 Entrez Gene 81004 MouseEntrez Gene 365755 RatEntrez Gene 79718 Human UniProt ID Q9BZK7
Background	This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]
Synonyms	C21; DC42; IRA1; MRD41; TBLR1
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Wnt signaling pathway

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