TBLR1 (TBL1XR1) Mouse Monoclonal Antibody [Clone ID: OTI2A8]

Specifications

Product Data
Clone Name	OTI2A8
Applications	WB
Recommend Dilution	WB 1:500~2000
Reactivity	Human, Rat, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human TBL1XR1 (NP_078941) produced in E.coli.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	55.4 kDa
Gene Name	TBL1X receptor 1
Database Link	NP_078941 Entrez Gene 81004 MouseEntrez Gene 365755 RatEntrez Gene 79718 Human UniProt ID Q9BZK7
Background	This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]
Synonyms	C21; DC42; IRA1; MRD41; TBLR1
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Wnt signaling pathway

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