Cullin 4B (CUL4B) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI1C4]

Specifications

Product Data
Clone Name	OTI1C4
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:100
Reactivity	Human, Dog, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 1-300 of human CUL4B (NP_003579) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.5 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	103.8 kDa
Gene Name	cullin 4B
Database Link	NP_003579 Entrez Gene 72584 MouseEntrez Gene 302502 RatEntrez Gene 492102 DogEntrez Gene 8450 Human UniProt ID Q13620
Background	This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms	CUL-4B; MRXHF2; MRXS15; MRXSC; SFM2
Reference Data
Protein Pathways	Nucleotide excision repair, Ubiquitin mediated proteolysis

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