LGR5 Mouse Monoclonal Antibody [Clone ID: OTI2A2]

CAT＃: TA503316

LGR5 mouse monoclonal antibody, clone OTI2A2

Conjugation: DyLight488 DyLight550 DyLight633 PE

Datasheet
SDS

  View other "OTI2A2" antibodies (2)

Need it in bulk or conjugated?
Get a free quote

CNY 1,999.00

CNY 2,700.00

货期*
现货
规格
    • 100 ul
Cited in 39 publications.
经常一起买 (2)
LY401213
Transient overexpression lysate of leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5)
    • 100 ug

CNY 4,840.00

添加到购物车
TA811000S
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

CNY 300.00
CNY 1,430.00

添加到购物车

【特别福利】购一抗正装产品（≥50ul或≥50ug），免费领10ul抗体试用装

Specifications

Product Data
Clone Name OTI2A2
Applications FC, IF, IHC, IP, WB
Recommend Dilution WB 1:2000, IHC 1:150, IF 1:100, FLOW 1:100, IP 2ug/500ul
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 250-550 of human LGR5 (NP_003658) produced in HEK293T Cell.
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size 99.8 kDa
Database Link
Synonyms FEX; GPR49; GPR67; GRP49; HG38
Reference Data
Protein Families Druggable Genome, GPCR, Transmembrane
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (39)

The use of this Antibodies has been cited in the following citations:
TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal. ,null, Cellular & molecular immunology ,PubMed ID 36596873 [LGR5]
L-glutamate requires β-catenin signalling through Frizzled7 to stimulate porcine intestinal stem cell expansion. ,null, Cellular and molecular life sciences : CMLS ,PubMed ID 36121491 [LGR5]
Lysine Interacts with Frizzled7 to Activate β-Catenin in Satellite Cell-Participated Skeletal Muscle Growth. ,null, Journal of agricultural and food chemistry ,PubMed ID 35312309 [LGR5]
Long noncoding RNA Gm31629 protects against mucosal damage in experimental colitis via YB-1/E2F pathway ,null, JCI Insight ,PubMed ID 35143419 [LGR5]
l-Carnosine Protects Against Deoxynivalenol-Induced Oxidative Stress in Intestinal Stem Cells by Regulating the Keap1/Nrf2 Signaling Pathway. ,null, Molecular nutrition & food research ,PubMed ID 34216418 [LGR5]
Lycopene Protects Intestinal Epithelium from Deoxynivalenol-Induced Oxidative Damage via Regulating Keap1/Nrf2 Signaling ,null, Antioxidants ,PubMed ID 34573125 [LGR5]
Colon Crypts of Subjects With Familial Adenomatous Polyposis Show an Increased Number of LGR5+ Ectopic Stem Cells ,Jennelle, LT;Dampier, CH;Tring, S;Powell, S;Casey, G;, Clinical and translational gastroenterology ,PubMed ID 33999013 [LGR5]
Robust Three-dimensional (3D) Expansion of Bovine Intestinal Stem Cells: A Model for Replacement of Animal Experiments ,Lee, B;Yang, H;Lee, S;Haq, I;Ock, S;Wi, H;Lee, H;Lee, P;Ryu, J;, Research Square [LGR5]
Evaluation of Intestinal Epithelial Barrier Function in Inflammatory Bowel Diseases Using Murine Intestinal Organoids ,Rallabandi, HR;Yang, H;Oh, KB;Lee, HC;Byun, SJ;Lee, BR;, Tissue Eng Regen Med ,PubMed ID 32594459 [LGR5]
FoxA2 inhibits the proliferation of hepatic progenitor cells by reducing PI3K/Akt/HK2-mediated glycolysis ,Wang, P;Cong, M;Liu, T;Li, Y;Liu, L;Sun, S;Sun, L;Zhu, Z;Ma, H;You, H;Zhang, H;Jia, J;, J. Cell. Physiol. ,PubMed ID 32495363 [LGR5]
LGR5+ epithelial tumor stem-like cells generate a 3D-organoid model for ameloblastoma ,null, Cell Death & Disease ,PubMed ID 32382005 [LGR5]
Wnt/β-catenin-mediated heat exposure inhibits intestinal epithelial cell proliferation and stem cell expansion through endoplasmic reticulum stress ,Zhou, JY;Huang, DG;Zhu, M;Gao, CQ;Yan, HC;Li, XG;Wang, XQ;, J. Cell. Physiol. ,PubMed ID 31960439 [LGR5]
Engineering a Bioartificial Human Colon Model Through Decellularization and Recellularization ,Chen, HJ;Shuler, ML;, Methods Mol. Biol. ,PubMed ID 30542993 [LGR5]
Clinicopathologic and prognostic significance of LGR5, a cancer stem cell marker in patients with colorectal cancer ,Ihemelandu, C;Naeem, A;Parasido, E;Berry, D;Chaldekas, K;Harris, B;Rodriguez, O;Albanese, C;, Colorectal Cancer ,PubMed ID 32038737 [LGR5]
Detection of circulating colorectal cancer cells by a custom microfluid system before and after endoscopic metallic stent placement ,Ishibashi, R;Yoshida, S;Odawara, N;Kishikawa, T;Kondo, R;Nakada, A;Hakuta, R;Takahara, N;Tanaka, E;Sekiba, K;Seimiya, T;Ohnaga, T;Otsuka, M;Koike, K;, Oncol Lett ,PubMed ID 31807163 [LGR5]
Methionine and its Hydroxyl Analogs Improve Stem Cell Activity to Eliminate Deoxynivalenol-Induced Intestinal Injury by Reactivating Wnt/β-catenin Signaling ,Zhou, JY;Wang, Z;Zhang, SW;Lin, HL;Gao, CQ;Zhao, JC;Yang, C;Wang, XQ;, J. Agric. Food Chem. ,PubMed ID 31532211 [LGR5]
Surface expression marker profile in colon cancer cell lines and sphere-derived cells suggests complexity in CD26+ cancer stem cells subsets ,Vázquez-Iglesias, L;Barcia-Castro, L;Rodríguez-Quiroga, M;Páez de la Cadena, M;Rodríguez-Berrocal, J;Cordero, OJ;, Biol Open ,PubMed ID 31285270 [LGR5]
Hydrolyzed wheat gluten alleviates deoxynivalenol-induced intestinal injury by promoting intestinal stem cell proliferation and differentiation via upregulation of Wnt/β-catenin signaling in mice ,Zhou, JY;Zhang, SW;Lin, HL;Gao, CQ;Yan, HC;Wang, XQ;, Food Chem. Toxicol. ,PubMed ID 31202940 [LGR5]
Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis ,Liu, R;Moriggl, R;Zhang, D;Li, H;Karns, R;Ruan, HB;Niu, H;Mayhew, C;Watson, C;Bangar, H;Cha, SW;Haslam, D;Zhang, T;Gilbert, S;Li, N;Helmrath, M;Wells, J;Denson, L;Han, X;, Life Sci Alliance ,PubMed ID 30948494 [LGR5]
Selection of a Malignant Subpopulation from a Colorectal Cancer Cell Line ,Lai, PL;Chen, TC;Feng, CY;Lin, H;Wu, N;Chen, Y;, bioRxiv [LGR5]
Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/β-catenin pathway ,Li, XG;Zhu, M;Chen, MX;Fan, HB;Fu, HL;Zhou, JY;, Toxicology Letters ,PubMed ID 30690062 [LGR5]
Resveratrol reduces senescence-associated secretory phenotype by SIRT1/NF-κB pathway in gut of the annual fish Nothobranchius guentheri ,Liu, S;Zheng, Z;Ji, S;Liu, T;Hou, Y;Li, S;Li, G;, Fish Shellfish Immunol. ,PubMed ID 29908321 [LGR5]
NANOGP8 is the key regulator of stemness, EMT, Wnt pathway, chemoresistance, and other malignant phenotypes in gastric cancer cells ,Ma, X;Wang, B;Wang, X;Luo, Y;Fan, W;, PLoS ONE ,PubMed ID 29689047 [LGR5]
Liver damage, proliferation, and progenitor cell markers in experimental necrotizing enterocolitis ,Miyake, H;Li, B;Lee, C;Koike, Y;Chen, Y;Seo, S;Pierro, A;, J. Pediatr. Surg. ,PubMed ID 29502797 [LGR5]
Identification of PMN-released Mutagenic Factors in a Co-culture Model for Colitis-associated Cancer ,Granofszky, N;Lang, M;Khare, V;Schmid, G;Scharl, T;Ferk, F;Jimenez, K;Knasmüller, S;Campregher, C;Gasche, C;, Carcinogenesis ,PubMed ID 29106440 [LGR5]
Immuno-proteomic discovery of tumor tissue autoantigens identifies olfactomedin 4, CD11b, and integrin alpha-2 as markers of colorectal cancer with liver metastases ,Yang, Q;Bavi, P;Wang, JY;Roehrl, MH;, J Proteomics ,PubMed ID 28669815 [LGR5]
LGR5 Is a Gastric Cancer Stem Cell Marker Associated with Stemness and the EMT Signature Genes NANOG, NANOGP8, PRRX1, TWIST1, and BMI1 ,Wang, B;Chen, Q;Cao, Y;Ma, X;Yin, C;Jia, Y;Zang, A;Fan, W;, PLoS ONE ,PubMed ID 28033430 [LGR5]
Heparan sulfate hexasaccharide selectively inhibits cancer stem cells self-renewal by activating p38 MAP kinase ,Patel, NJ;Sharon, C;Baranwal, S;Boothello, RS;Desai, UR;Patel, BB;, Oncotarget ,PubMed ID 27705927 [LGR5]
A recellularized human colon model identifies cancer driver genes ,Chen, HJ;Wei, Z;Sun, J;Bhattacharya, A;Savage, DJ;Serda, R;Mackeyev, Y;Curley, SA;Bu, P;Wang, L;Chen, S;Cohen-Gould, L;Huang, E;Shen, X;Lipkin, SM;Copeland, NG;Jenkins, NA;Shuler, ML;, Nat. Biotechnol. ,PubMed ID 27398792 [LGR5]
Full-length LGR5-positive cells have chemoresistant characteristics in colorectal cancer ,Osawa, H;Takahashi, H;Nishimura, J;Ohta, K;Haraguchi, N;Hata, T;Yamamoto, H;Mizushima, T;Takemasa, I;Doki, Y;Mori, M;, Br. J. Cancer ,PubMed ID 27140312 [LGR5]
Comparison of leucine-rich repeat-containing G protein-coupled receptor 5 expression in different cancer and normal cell lines ,null, Biomedical Reports ,PubMed ID 27347416 [LGR5]
Inhibition of insulin-like growth factor receptor/AKT/mammalian target of rapamycin axis targets colorectal cancer stem cells by attenuating mevalonate-isoprenoid pathway in vitro and in vivo ,null, Oncotarget ,PubMed ID 25895029 [LGR5]
LGR5 activates non-canonical Wnt-signaling and inhibits aldosterone production in the human adrenal ,Shaikh, LH;Zhou, J;Teo, AE;Garg, S;Neogi, SG;Figg, N;Yeo, GS;Yu, H;Maguire, JJ;Zhao, W;Bennett, MR;Azizan, EA;Davenport, AP;McKenzie, G;Brown, MJ;, J. Clin. Endocrinol. Metab. ,PubMed ID 25915569 [LGR5]
CBB1003, a lysine-specific demethylase 1 inhibitor, suppresses colorectal cancer cells growth through down-regulation of leucine-rich repeat-containing G-protein-coupled receptor 5 expression ,Hsu, HC;Liu, YS;Tseng, KC;Yang, TS;Yeh, CY;You, JF;Hung, HY;Chen, SJ;Chen, HC;, J. Cancer Res. Clin. Oncol. July 2014 ,PubMed ID 25060070 [LGR5]
[Human; IHC]
LGR5 regulates survival through mitochondria-mediated apoptosis and by targeting the Wnt/ß-catenin signaling pathway in colorectal cancer cells ,Hsu, HC;Liu, YS;Tseng, KC;Tan, BC;Chen, SJ;Chen, HC;, Cell. Signal. July 2014 ,PubMed ID 25025569 [LGR5]
[Human; WB]
Identification of a distinct small cell population from human bone marrow reveals its multipotency in vivo and in vitro ,Wang, J;Guo, X;Lui, M;Chu, PJ;Yoo, J;Chang, M;Yen, Y;, PLoS ONE, Jan 2014. ,PubMed ID 24465489 [LGR5]
[Human; FC]
Postnatal epithelium and mesenchyme stem/progenitor cells in bioengineered amelogenesis and dentinogenesis ,Jiang, N;Zhou, J;Chen, M;Schiff, MD;Lee, CH;Kong, K;Embree, MC;Zhou, Y;Mao, JJ;, Biomaterials Dec 2013. ,PubMed ID 24345734 [Lgr5]
[Rat; IF]
Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers ,Chen Wu, Yuanyuan Xie, Feng Gao, Yanan Wang, Yawei Guo, Huanna Tian, Yanshuang Li, Wufang Fan, Gene. 2013 Aug 1;525(1):18-25 ,PubMed ID 23664892 [LGR5]
PKH26 staining defines distinct subsets of normal human colon epithelial cells at different maturation stages ,Pastò A, Marchesi M, Diamantini A, Frasson C, Curtarello M, Lago C, Pilotto G, Parenti AR, Esposito G, Agostini M, Nitti D, Amadori A, PLoS One. 2012;7(8):e43379 ,PubMed ID 22927961 [LGR5]

Other Versions

SKU Description Size Price
CF503316 Carrier-free (BSA/glycerol-free) LGR5 mouse monoclonal antibody, clone OTI2A2 (formerly 2A2)
    • 100 ug

CNY 3,999.00

TA503316S LGR5 mouse monoclonal antibody, clone OTI2A2
    • 30 ul

CNY 800.00

其它LGR5产品

Expression Plasmids
Lentiviral Particles
CRISPR
RNAi
Proteins
Antibodies
相关产品 (3)

CF503316

Carrier-free (BSA/glycerol-free) LGR5 mouse monoclonal antibody, clone OTI2A2 (formerly 2A2)

    • 100 ug

CNY 3,999.00 暂停销售

TA811000

beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control

【特别福利】购一抗正装产品（≥50ul或≥50ug），免费领10ul抗体试用装

    • 100 ul

CNY 600.00

TA802519

Mouse monoclonal anti-GAPDH antibody, clone OTI2D9 (formerly 2D9), loading control

【特别福利】购一抗正装产品（≥50ul或≥50ug），免费领10ul抗体试用装

    • 100 ul

CNY 600.00

Previous
Next
Customer Reviews