CD5 Mouse Monoclonal Antibody [Clone ID: OTI6F7]

Specifications

Product Data
Clone Name	OTI6F7
Applications	FC, IHC, WB
Recommend Dilution	WB 1:500~2000, FLOW 1:100
Reactivity	Human, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human CD5 (NP_055022) produced in HEK293T cell.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.96 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	54.4 kDa
Gene Name	CD5 molecule
Database Link	NP_055022 Entrez Gene 695249 MonkeyEntrez Gene 921 Human UniProt ID P06127
Background	CD5 (Lymphocyte antigen T1/Leu-1) is a transmembrane glycoprotein which has been implicated as a receptor in the regulation of T-cell proliferation (1). CD5 is part of the scavenger receptor cysteine-rich (SRCR) family group B and it is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by T cell leukemia, lymphomas, and activated T cells. Occasionally, CD5 antigen is also expressed on a subset of B cells. Mantle cell lymphomas (same as diffuse centrocytic lymphomas) are CD5+ while the follicle center cell lymphomas are CD5. A ligand for CD72/LYB-2, CD5 has been linked to negative regulation of T cell and B cell receptors signaling (2).
Synonyms	LEU1; T1
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Hematopoietic cell lineage

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