KEAP1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500-1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-Keap1 Antibody: A synthesized peptide derived from human Keap1
Formulation	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 ?.Stable for 12 months from date of receipt
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	70 kDa
Gene Name	kelch like ECH associated protein 1
Database Link	NP_036421 Entrez Gene 50868 MouseEntrez Gene 117519 RatEntrez Gene 9817 Human UniProt ID Q14145
Background	Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.
Synonyms	INrf2; KLHL19
Note	Keap1 Antibody detects endogenous levels of total Keap1
Reference Data
Protein Families	Transcription Factors
Protein Pathways	Ubiquitin mediated proteolysis

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