RAD51 Mouse Monoclonal Antibody [Clone ID: 4H10-G5-H4]

Specifications

Product Data
Clone Name	4H10-G5-H4
Applications	WB
Recommend Dilution	WB: 1:1000
Reactivity	Human, Mouse, Rat, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for RAD51 antibody: Recombinant protein of human Rad51.
Formulation	0.03% Proclin300 and 50% glycerol.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	37 kDa
Gene Name	RAD51 recombinase
Database Link	NP_002866 Entrez Gene 19361 MouseEntrez Gene 499870 RatEntrez Gene 5888 Human UniProt ID Q06609
Background	The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms	BRCC5; FANCR; HRAD51; HsRad51; HsT16930; MRMV2; RAD51A; RECA
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways	Homologous recombination, Pancreatic cancer, Pathways in cancer

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