elF2 alpha (EIF2S1) Mouse Monoclonal Antibody [Clone ID: 2E4-F5-E7]

Specifications

Product Data
Clone Name	2E4-F5-E7
Applications	IF, IP, WB
Recommend Dilution	WB: 1:1000
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for EIF2S1 antibody: purified recombinant human eIF2a protein fragments expressed in E.coli.
Formulation	PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	eukaryotic translation initiation factor 2 subunit alpha
Database Link	NP_004085 Entrez Gene 54318 RatEntrez Gene 1965 Human UniProt ID P05198
Background	The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).
Synonyms	EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A
Reference Data

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