E2F1 Mouse Monoclonal Antibody [Clone ID: 4G8-2C2-C12]
CAT#: TA346935S
Mouse Monoclonal E2F-1 Antibody
Size: 100 ul
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Specifications
Product Data | |
Clone Name | 4G8-2C2-C12 |
Applications | IF, IP, WB |
Recommend Dilution | WB: 1:500, IF: 1:100 |
Reactivity | Human, Rat |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | The immunogen for E2F1 antibody: purified recombinant human E2F-1 protein fragments expressed in E.coli. |
Formulation | Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol. |
Purification | Affinity purified |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | E2F transcription factor 1 |
Database Link | |
Background | The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. |
Synonyms | E2F-1; RBAP1; RBBP3; RBP3 |
Reference Data | |
Protein Families | Druggable Genome, Transcription Factors |
Protein Pathways | Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer |
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