E2F1 Mouse Monoclonal Antibody [Clone ID: 4G8-2C2-C12]

Specifications

Product Data
Clone Name	4G8-2C2-C12
Applications	IF, IP, WB
Recommend Dilution	WB: 1:500, IF: 1:100
Reactivity	Human, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	The immunogen for E2F1 antibody: purified recombinant human E2F-1 protein fragments expressed in E.coli.
Formulation	Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
Purification	Affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	E2F transcription factor 1
Database Link	NP_005216 Entrez Gene 1869 Human UniProt ID Q01094
Background	The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Synonyms	E2F-1; RBAP1; RBBP3; RBP3
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer

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