Calreticulin (CALR) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	Block/Neutralize, Dot, Electron Microscopy, FC, ICC/IF, IHC, IP, Protein Array, Simple Western, WB
Recommend Dilution	Protein Array, Immunoprecipitation, Flow Cytometry, Knockdown Validated: 1:1500, Western Blot: 1:1000, Simple Western: 1:50, Immunohistochemistry: 1:50 - 1:200, Immunohistochemistry-Paraffin: 1:50 -1:200, Immunocytochemistry/ Immunofluorescence: 1:50-1:250, Block/Neutralize, Dot Blot, Electron Microscopy
Reactivity	Human, Mouse, Rat, Bovine, Hamster, Primate
Host	Rabbit
Clonality	Polyclonal
Immunogen	A fusion protein to mouse Calreticulin [UniProt# P14211]
Formulation	PBS, 30% glycerol, 0.1% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	calreticulin
Database Link	NP_004334 Entrez Gene 12317 MouseEntrez Gene 64202 RatEntrez Gene 811 Human UniProt ID P27797
Background	Calreticulin is a multifunctional, highly conserved Ca2+ -binding protein that is localized to the endoplasmic reticulum (ER). It is also a molecular chaperone and is involved in protein folding events in the ER. Calreticulin has also been shown to interact with the cytoskeleton and to be involved in the regulation of gene expression. Calreticulin may play a role in cellular proliferation including its apparent activity in the proliferation of certain viruses within mammalian host cells. (2-3) Recently it has been shown that calreticulin is induced in response to various types of cell stress including amino acid deprivation. (1) Close interconnections among protein synthesis, gene expression and calcium signaling have been observed by many researchers in recent years. Calreticulin might be centrally located and crucially participate in the coordination of these functions by the cell.(2-3)
Synonyms	cC1qR; CRT; HEL-S-99n; RO; SSA
Note	This Calreticulin antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry and Western blot, where a band is observed at ~55 kDa. Electron Microscopy, Blocking/Neutralizing, Dot Blot, Immunoprecipitation and Protein Array were reported in scientific literature.
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transcription Factors
Protein Pathways	Antigen processing and presentation

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