PCNA Mouse Monoclonal Antibody [Clone ID: 1157CT1.1.3]

Specifications

Product Data
Clone Name	1157CT1.1.3
Applications	WB
Recommend Dilution	WB: 1:2000
Reactivity	Human, Mouse, Rat, Bovine, Hamster, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	This PCNA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 236-261 amino acids from the C-terminal region of human PCNA.
Formulation	PBS with 0.09% (W/V) sodium azide
Concentration	lot specific
Purification	This antibody is purified through a protein G column, followed by dialysis against PBS.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	proliferating cell nuclear antigen
Database Link	NP_872590 Entrez Gene 18538 MouseEntrez Gene 25737 RatEntrez Gene 718006 MonkeyEntrez Gene 5111 Human UniProt ID P12004
Background	This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2.
Synonyms	ATLD2
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Base excision repair, Cell cycle, DNA replication, Mismatch repair, Nucleotide excision repair

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