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Macrophage Scavenger Receptor I (MSR1) Rabbit Polyclonal Antibody
CAT＃: TA327214S
MSR1 Rabbit Polyclonal Antibody
Size: 100 ul
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CN¥ 800.00
货期*
2周
规格
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Specifications
| Product Data | |
| Applications | ICC/IF, WB |
| Recommend Dilution | WB 1:500 - 1:2000 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Immunogen | Recombinant protein of human MSR1 |
| Formulation | PBS with 0.09% Sodium azide,50% glycerol,pH7.3. |
| Concentration | lot specific |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage Condition | Store at -20°C as received. |
| Predicted Protein Size | 50 kDa |
| Gene Name | macrophage scavenger receptor 1 |
| Database Link | |
| Background | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimers disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008] |
| Synonyms | CD204; phSR1; phSR2; SCARA1; SR-A; SRA |
| Reference Data | |
| Protein Families | Druggable Genome, Transmembrane |
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