Superoxide Dismutase 3 (SOD3) Mouse Monoclonal Antibody [Clone ID: 4GG11G6]

Specifications

Product Data
Clone Name	4GG11G6
Applications	IF
Recommend Dilution	WB: 1:1000, IHC: 1:100, ICC: 1:100
Reactivity	Human, Rat, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Human EC SOD purified from aortas
Formulation	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	superoxide dismutase 3, extracellular
Database Link	NP_003093 Entrez Gene 20657 MouseEntrez Gene 25352 RatEntrez Gene 6649 Human UniProt ID P08294
Background	Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body . It works by catalyzing the dismutation of the superoxide radical O2? to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase . In general, SODs play a major role in antioxidant defense mechanisms . There are three types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge . The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space . SOD3 can also be distinguished by its heparin-binding capacity .
Synonyms	EC-SOD
Note	Detects EC SOD at ~35kDa.
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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