IL1RAP Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Hela cell, Mouse heart tissue, Human cerebella tissue, Human cerebrum tissue lysates IHC: 50-200 Positive control: Human gastric cancer Predicted cell location: Secreted
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 22-356 amino acids of Human Interleukin-1 receptor accessory protein
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	interleukin 1 receptor accessory protein
Database Link	NP_608273 Entrez Gene 16180 MouseEntrez Gene 25466 RatEntrez Gene 3556 Human UniProt ID Q9NPH3
Background	Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection; tissue damage; or stress; by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms; one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress.
Synonyms	C3orf13; IL-1RAcP; IL1R3
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Apoptosis, Cytokine-cytokine receptor interaction

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