RRM1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Hela and 231 cells IHC: 25-100 Positive control: Human liver cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to C terminal 226 amino acids of human ribonucleotide reductase M1
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	90 kDa
Gene Name	ribonucleotide reductase catalytic subunit M1
Database Link	NP_001024 Entrez Gene 20133 MouseEntrez Gene 6240 Human UniProt ID P23921
Background	This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase; an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5; an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome; Wilms tumor; rhabdomyosarcoma; adrenocrotical carcinoma; and lung; ovarian; and breast cancer. This gene may play a role in malignancies and disease that involve this region.
Synonyms	R1; RIR1; RR1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism

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