RRM1 (NM_001033) Human Recombinant Protein
CAT#: TP300726
Recombinant protein of human ribonucleotide reductase M1 (RRM1), 20 µg
View other "RRM1" proteins (3)
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Avi-tag Biotinylated Protein Get a free quote |
CNY 2,900.00
CNY 6,650.00
Cited in 1 publication. |
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Specifications
Product Data | |
Species | Human |
Expression Host | HEK293T |
Expression cDNA Clone or AA Sequence |
>Peptide sequence encoded by RC200726
Blue=ORF Red=Cloning site Green=Tag(s) MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAATLTT KHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYD RDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFN AGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPML RVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETN QDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRK SNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDI NYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGP YETYEGSPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYT SNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKT VLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKD KEKVSKEEEEKERNTAAMVCSLENRDECLMCGS TRTRPLEQKLISEEDLAANDILDYKDDDDKV Recombinant protein using RC200726 also available, TP300726 |
Tag | C-Myc/DDK |
Predicted MW | 89.9 kDa |
Concentration | >0.05 µg/µL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Bioactivity | Binding assay (PMID: 29765556) |
Reference Data | |
RefSeq | NP_001024 |
Locus ID | 6240 |
UniProt ID | P23921 |
Refseq Size | 3117 |
Cytogenetics | 11p15.4 |
Refseq ORF | 2376 |
Synonyms | R1; RIR1; RR1 |
Summary | This gene encodes the large and catalytic subunit of ribonucleotide reductase, an enzyme essential for the conversion of ribonucleotides into deoxyribonucleotides. A pool of available deoxyribonucleotides is important for DNA replication during S phase of the cell cycle as well as multiple DNA repair processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
Protein Families | Druggable Genome |
Protein Pathways | Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism |
Citations (1)
The use of this Proteins has been cited in the following citations: |
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Antibody-assisted target identification reveals afatinib, an EGFR covalent inhibitor, down-regulating ribonucleotide reductase
,Yu, CH;Chou, CC;Tu, HF;Huang, WC;Ho, YY;Khoo, KH;Lee, MS;Chang, GD;,
Oncotarget
,PubMed ID 29765556
[RRM1]
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Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC422336 | RRM1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
LY422336 | Transient overexpression lysate of ribonucleotide reductase M1 (RRM1) |
CNY 3,080.00 |
|
PH300726 | RRM1 MS Standard C13 and N15-labeled recombinant protein (NP_001024) |
CNY 19,520.00 |