Profilin 2 (PFN2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 500-2000 WB positive control: Human fetal brain tissue IHC: 25-100 Positive control: Human brain Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 128-140 amino acids of Human profilin 2
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	15 kDa
Gene Name	profilin 2
Database Link	NP_444252 Entrez Gene 18645 MouseEntrez Gene 81531 RatEntrez Gene 5217 Human UniProt ID P35080
Background	The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. Binds to actin and affects the structure of the cytoskeleton. At high concentrations; profilin prevents the polymerization of actin; whereas it enhances it at low concentrations. By binding to PIP2; it inhibits the formation of IP3 and DG.
Synonyms	D3S1319E; PFL
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Regulation of actin cytoskeleton

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