PKR (EIF2AK2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human breast cancer Predicted cell location: Cytoplasm
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 438-451 amino acids of Human eukaryotic translation initiation factor 2-alpha kinase 2
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	eukaryotic translation initiation factor 2 alpha kinase 2
Database Link	NP_002750 Entrez Gene 5610 Human UniProt ID P19525
Background	The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1; which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene
Synonyms	EIF2AK1; PKR; PPP1R83; PRKR
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Transcription Factors

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