CD10 (MME) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	IHC: 50-200 Positive control: Human brain Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide peptide corresponding to a region derived from 519-533 amino acids of human membrane metallo-endopeptidase
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	membrane metallo-endopeptidase
Database Link	NP_000893 Entrez Gene 17380 MouseEntrez Gene 24590 RatEntrez Gene 4311 Human UniProt ID P08473
Background	This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype; which represent 85% of cases of ALL. This protein is not restricted to leukemic cells; however; and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney; where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon; enkephalins; substance P; neurotensin; oxytocin; and bradykinin. This gene; which encodes a 100-kD type II transmembrane glycoprotein; exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced; resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.?
Synonyms	CALLA; CD10; CMT2T; NEP; SCA43; SFE
Reference Data
Protein Families	Druggable Genome, Protease, Transmembrane
Protein Pathways	Alzheimer's disease, Hematopoietic cell lineage, Renin-angiotensin system

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