Calreticulin (CALR) Rabbit Polyclonal Antibody

CAT#: TA309300

Rabbit Polyclonal anti-CALR Antibody



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CNY 4,650.00


货期*
4周

规格
    • 200 ul

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经常一起买 (4)
Transient overexpression lysate of calreticulin (CALR)
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beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
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Recombinant protein of human calreticulin (CALR), 20 µg
    • 20 ug

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Recombinant protein of human calreticulin (CALR), 100 µg
    • 100 ug

CNY 9,998.00

Specifications

Product Data
Applications IF, WB
Recommend Dilution WB 1:5000; IF
Reactivity Human, Mouse, Rat, Bovine, Dog, Chicken, Drosophila, Fish, Monkey, Porcine, Rabbit, Sheep, Hamster, Guinea Pig
Host Rabbit
Clonality Polyclonal
Immunogen Human calreticulin synthetic peptide with a cysteine residue added and the peptide conjugated to KLH
Formulation Rabbit Antiserum
Concentration lot specific
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name calreticulin
Background Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq]
Synonyms cC1qR; CRT; HEL-S-99n; RO; SSA
Reference Data
Protein Families Druggable Genome, Secreted Protein, Transcription Factors
Protein Pathways Antigen processing and presentation
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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