ARMET (MANF) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC, WB
Recommend Dilution	WB: 0.125-2 µg/mL; IHC: 2.5 µg/mL; IF: 20 µg/mL Antibody validated: Western Blot in human, mouse and rat samples; Immunohistochemistry in human samples; Immunofluorescence in human samples. All other applications and species not yet tested.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	MANF antibody was raised against a 12 amino acid peptide from near the carboxy terminus of human MANF.
Specificity	This antibody does not cross-react with CDNF.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	MANF Antibody is Protein A purified.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	mesencephalic astrocyte derived neurotrophic factor
Database Link	NP_006001 Entrez Gene 74840 MouseEntrez Gene 315989 RatEntrez Gene 7873 Human UniProt ID P55145
Background	MANF, also known as ARMET, was initially identified as a protein containing an arginine-rich region that was highly mutated in a variety of tumors. More recently it was identified as a mesencephalic astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons, similar to glial cell line-derived neurotrophic factor (GDNF) and CDNF. In rat brain slices, MANF enhanced nigral gamma-aminobutyric acid release. Like GDNF and CDNF, MANF has selective neuroprotective activity for dopaminergic neurons suggesting that it may be indicated for the treatment of Parkinson’s disease. Expression of MANF has also been shown to be induced during ER stress, suggesting that it may play a role in protein quality control during ER stress. This antibody does not cross-react with CDNF.
Synonyms	ARMET; ARP
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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