APE1 (APEX1) Mouse Monoclonal Antibody [Clone ID: 13B8E5C2]

Specifications

Product Data
Clone Name	13B8E5C2
Applications	ChIP, ELISA, ICC/IF, IHC, Immunoblotting, IP, Simple Western, WB
Recommend Dilution	Proximity Ligation Assay, Immunoblotting, ELISA, Chromatin Immunoprecipitation (ChIP): 1:10-1:500, Immunoprecipitation: 1:10 - 1:500, Immunohistochemistry-Frozen: 1:10-1:500, Immunohistochemistry: 1:100, Immunohistochemistry-Paraffin: 1:100, Western Blot: 1:100-1:2000, Simple Western: 1:25, Immunocytochemistry/ Immunofluorescence: 1:50-1:200, Gel Super Shift Assays, Knockdown Validated
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	A fusion protein construct that contains the N-terminal region of human ACAT1.
Formulation	PBS and 0.05% sodium azide
Purification	Purified human APE/ref protein.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	apurinic/apyrimidinic endodeoxyribonuclease 1
Database Link	NP_001632 Entrez Gene 11792 MouseEntrez Gene 79116 RatEntrez Gene 328 Human UniProt ID P27695
Background	The mammalian apurinic/apyrimidinic endonuclease (APE/ref-1) is responsible for the repair of AP sites in DNA. In addition, this enzyme functions as a redox factor facilitating the DNA binding capability of FOS, JUN, NfkB, HIF-1 alpha, Pax-5, Pax-8 and other transcription factors. APE/ref-1 has also been shown to control p53 activity through redox alteration. APE is linked to apoptosis, associated with thioredoxin, and altered levels of APE/ref-1 have been found in some cancers. APE appears to form a unique link between the DNA base excision pathway, oxidative signaling, transcription regulation, cancer and cell-cycle control.
Synonyms	APE; APE1; APEN; APEX; APX; HAP1; REF1
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transcription Factors
Protein Pathways	Base excision repair

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