REA Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:1000, IHC: 1:10~50
Reactivity	Mouse, Rat, Bovine, Human, Chicken
Host	Rabbit
Clonality	Polyclonal
Immunogen	This REA (PHB2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-95 amino acids from the N-terminal region of human REA (PHB2).
Formulation	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Concentration	lot specific
Purification	This antibody is purified through a protein G column, followed by dialysis against PBS.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Database Link	NP_009204 Entrez Gene 12034 MouseEntrez Gene 114766 Rat
Background	PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. It competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging.
Synonyms	BAP; Bap37; BCAP37; p22; PNAS-141; REA
Reference Data
Protein Families	Druggable Genome, Transcription Factors

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