CD33 Mouse Monoclonal Antibody [Clone ID: HIM3-4]

Specifications

Product Data
Clone Name	HIM3-4
Applications	FC
Recommend Dilution	Indirect Immunofluorescence analysis by Flow Cytometry (1/1000).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	NFMY-9s Human cell line.
Specificity	The antibody HIM3-4 reacts with CD33, a 67 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells; it is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells. HLDA V; WS Code M MA112. HLDA VI; WS Code M MA47.
Formulation	PBS, pH~7.4 Label: Biotin State: Liquid purified Ig fraction Preservative: 15 mM Sodium Azide Label: -LC-NHS, The reagent is free of unconjugated Biotin.
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Biotin
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	CD33 molecule
Database Link	Entrez Gene 945 Human UniProt ID P20138
Background	CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia.
Synonyms	Siglec-3, gp67
Reference Data

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