Amylin (IAPP) Mouse Monoclonal Antibody [Clone ID: R10/99]

Specifications

Product Data
Clone Name	R10/99
Applications	IF, IHC
Recommend Dilution	Immunocytochemistry/Immunofluorescence: 1/10-1/500.  Immunohistochemistry on Frozen Sections: 1/100. Immunohistochemistry on Paraffin Sections: 1/100. This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide: CATQRLANFLV coupled to Tuberculin. Spleen cells from immunised BALB/c mouse were fused with cells of the mouse SP2/0 myeloma cell line.
Specificity	This antibody recognizes the islet Amyloid polypeptide. The antibody is of high affinity, and stains islet amyloid peptide in intra-cellular insulin granules, intra-cellular Amyloid and extra-cellular islet Amyloid.
Formulation	State: Supernatant State: Liquid Tissue Culture Supernatant Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	islet amyloid polypeptide
Database Link	Entrez Gene 3375 Human UniProt ID P10997
Background	Amylin is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring an insulinoma. While the assosciation of amylin with the development of type II diabetes has been known for some time, a direct causative role for amylin has been harder to establish. Recent results suggest that amylin, like the related beta amyloid (Abeta) assosciated with Alzheimer's disease, can induce apoptotic cell death in particular cultured cells, an effect that may be relevant to the development of type II diabetes.
Synonyms	AMYLIN; DAP; IAP
Reference Data

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