CTLA4 Mouse Monoclonal Antibody [Clone ID: OTI8F1]

Specifications

Product Data
Clone Name	OTI8F1
Applications	FC, WB
Recommend Dilution	WB 1:500
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human CTLA4 (NP_001032720) produced in HEK293T cell.
Formulation	Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)
Reconstitution Method	For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	15 kDa
Gene Name	cytotoxic T-lymphocyte associated protein 4
Database Link	NP_001032720 Entrez Gene 1493 Human UniProt ID P16410
Background	This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Synonyms	ALPS5; CD; CD152; CELIAC3; CTLA-4; GRD4; GSE; IDDM12
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Autoimmune thyroid disease, Cell adhesion molecules (CAMs), T cell receptor signaling pathway

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