Complement C3 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC
Recommend Dilution	Flow Cytometry: Use 1/50 as a typical starting working dilution.  Positive Control: Red Blood Cells.
Reactivity	Porcine
Host	Rabbit
Clonality	Polyclonal
Immunogen	Purified Pig C3
Specificity	The polyclonal antibody recognizes Pig complement component C3.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Database Link	UniProt ID P01025
Background	The complement system is an important part of the humoral response in innate immunity, consisting of three different pathways. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. The complement factor C3 consists of an alpha- and a beta-chain. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/ml. An inherited deficiency of C3 predisposes the person to frequent assaults of bacterial infections. In ulcerative colitis, and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. Proteolysis by certain enzymes results in the cleavage of C3 into C3a and C3b. C3b becomes attached to immune complexes and is further cleaved into iC3b, C3c, C3dg and C3f.
Synonyms	CPAMD1, Complement component 3
Reference Data

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