cAMP / cyclic AMP Rabbit Polyclonal Antibody
CAT#: AP23445SU-N
cAMP / cyclic AMP rabbit polyclonal antibody, Serum
Size: 20 ul
Need it in bulk or conjugated?
Get a free quote
CNY 7,161.00
货期*
5周
规格
Product images
![](https://cdn.origene.com/img/defaults-img.jpg)
Specifications
Product Data | |
Applications | R |
Recommend Dilution | RIA. Antigen binding capacity: Dilutions 1/5000 bound 45-50% of the labelled (radioactive) nucleotide. |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Succinyl cAMP- Human Serum Albumin conjugate |
Specificity | Cross-reactivity at 50% displacement: AMP < 0.00001% ADP < 0.00002% ATP < 0.00001% cGMP < 0.001% |
Formulation | State: Serum State: Lyophilized Serum |
Reconstitution Method | Restore in aqua bidest to initial volume. |
Conjugation | Unconjugated |
Storage Condition | Store lyophilized at 2-8°C and reconstituted at -20°C. Avoid repeated freezing and thawing. |
Background | Cyclic adenosine monophosphate (cAMP) plays a key role as an intracellular second messenger for transduction events that follow a number of extracellular signals. The G-Protein Coupled Receptors (GPCR) is the largest family of cell surface receptors. They can be activated by different ligands, such as neurotransmitters, hormones, ions, small molecules, peptides, and other physiological signaling molecules. Typically, the binding of the ligands to its receptor resulting in the activation of G-proteins, in return, activates the effector adenylyl cyclase evoking the production of cAMP. The activation of a protein kinase by cAMP results in the phosphorylation of substrate proteins. Currently successful drugs in marketing have been developed to target these receptors. Among the GPCRs, ~367 receptors are potential drug development targets, but only about 20 have been used to generate therapeutically and commercially successful drugs so far. Because the involvement of cAMP can amplify the response of the ligand binding, the second messenger cAMP has been largely employed to monitor the activation of the GPCR to facilitate the therapeutic drug discovery. |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Customer
Reviews
Loading...