cAMP / cyclic AMP Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	R
Recommend Dilution	RIA. Antigen binding capacity: Dilutions 1/5000 bound 45-50% of the labelled (radioactive) nucleotide.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Succinyl cAMP- Human Serum Albumin conjugate
Specificity	Cross-reactivity at 50% displacement: AMP < 0.00001% ADP < 0.00002% ATP < 0.00001% cGMP < 0.001%
Formulation	State: Serum State: Lyophilized Serum
Reconstitution Method	Restore in 20 µl aqua bidest
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C and reconstituted at -20°C. Avoid repeated freezing and thawing.
Background	Cyclic adenosine monophosphate (cAMP) plays a key role as an intracellular second messenger for transduction events that follow a number of extracellular signals. The G-Protein Coupled Receptors (GPCR) is the largest family of cell surface receptors. They can be activated by different ligands, such as neurotransmitters, hormones, ions, small molecules, peptides, and other physiological signaling molecules. Typically, the binding of the ligands to its receptor resulting in the activation of G-proteins, in return, activates the effector adenylyl cyclase evoking the production of cAMP. The activation of a protein kinase by cAMP results in the phosphorylation of substrate proteins. Currently successful drugs in marketing have been developed to target these receptors. Among the GPCRs, ~367 receptors are potential drug development targets, but only about 20 have been used to generate therapeutically and commercially successful drugs so far. Because the involvement of cAMP can amplify the response of the ligand binding, the second messenger cAMP has been largely employed to monitor the activation of the GPCR to facilitate the therapeutic drug discovery.
Reference Data

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