ARHGEF4 (143-271) Mouse Monoclonal Antibody [Clone ID: ARHGEF-08]
CAT#: AM26710RP-N
ARHGEF4 (143-271) mouse monoclonal antibody, clone ARHGEF-08, PE
Conjugation: Unconjugated
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CNY 4,340.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | ARHGEF-08 |
Applications | FC, WB |
Recommend Dilution | Flow Cytometry. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Recombinant fragment of human ARHGEF4 (amino acids 143-271) |
Specificity | This antobdy recognizes Human intracellular protein ARHGEF4 / ASEF1, approx. 80 kDa guanine nucleotide exchange factor specific for Rac1 and Cdc42. |
Formulation | PBS Label: PE State: Liquid purified Ig fraction Stabilizer: 0.2% (w/v) high-grade protease free BSA Preservative: 15 mM Sodium Azide Label: Conjugated with R-Phycoerythrin (PE) under optimum conditions. |
Concentration | lot specific |
Purification | Size Exclusion Chromatography |
Conjugation | PE |
Storage Condition | Store undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. |
Gene Name | Rho guanine nucleotide exchange factor 4 |
Database Link | |
Background | ARHGEF4 (Rho guanine nucleotide exchange factor 4), also known as ASEF 1 (adenomatous polyposis coli – stimulated guanine nucleotide exchange factor 1) is an approximately 80 kDa cytoplasmic protein important for growth factor-mediated regulation of cell morphology and migration. Besides N-terminal adenomatous polyposis coli (APC)-binding region (ABR) it contains Dbl homology (DH), Pleckstrin homology (PH) and SH3 domains. The SH3 domain inhibits GEF activity of ARHGEF4 by intramolecular interaction with the DH domain, whereas binding of APC stimulates the GEF activity. Activated ARHGEF4 stimulates the small GTPase Cdc42, which leads to decreased cell-cell adherence and enhanced cell migration. |
Synonyms | KIAA1112, ASEF |
Reference Data |
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