HLA Class II DR Mouse Monoclonal Antibody [Clone ID: L243]

CAT＃: AM26708PU-N

HLA Class II DR mouse monoclonal antibody, clone L243, Purified

Conjugation: Unconjugated APC FITC PE

Datasheet
SDS

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CNY 3,280.00

货期*
5周
规格
    • 100 ug
Cited in 8 publications.

Product images

Specifications

Product Data
Clone Name L243
Applications FC, FN, IF, IHC, IP, WB
Recommend Dilution Flow Cytometry.
Immunoprecipitation.
Western blot.
Immunohistochemistry on Paraffin Sections.
Immunohistochemistry on Frozen Sections.
Immunocytochemistry.
Functional Application: blocking.
Reactivity Canine, Human, Primate
Host Mouse
Clonality Monoclonal
Immunogen Human B lymphocytes
Specificity This antibody recognizes specifically HLA-DR molecules, both peptide-loaded and empty.
Formulation PBS, pH~7.4
State: Purified
State: Liquid purified IgG fraction (> 95% by SDS-PAGE)
Preservative: 15 mM Sodium Azide
Concentration lot specific
Purification Affinity Chromatography on Protein A
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C.
DO NOT FREEZE!
Background HLA-DR, a member of MHC class II glycoproteins, that bind intracellularly processed peptides and present them to the Th cells, is composed of 36 kDa alpha chain and 27 kDa beta chain, both anchored in the plasma membrane. Together with other MHC II molecules HLA-DR plays a central role in the immune system. It is expressed on antigen-presenting cells (dendritic cells, B lymphocytes, monocytes, macrophages).
Synonyms HLA-DR, HLA class II histocompatibility antigen DR, MHC class II antigen DR
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations (8)

The use of this Antibodies has been cited in the following citations:
MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation ,De Gassart A, Camosseto V, Thibodeau J, Ceppi M, Catalan N, Pierre P, Gatti E, Proc. Natl. Acad. Sci. U.S.A. ,PubMed ID 18305173
Normal human kidney HLA-DR-expressing renal microvascular endothelial cells: characterization, isolation, and regulation of MHC class II expression ,Muczynski KA, Ekle DM, Coder DM, Anderson SK, J. Am. Soc. Nephrol. ,PubMed ID 12707403
Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions ,Kalka-Moll WM, Tzianabos AO, Bryant PW, Niemeyer M, Ploegh HL, Kasper DL, J. Immunol. ,PubMed ID 12444118
Lipid raft-dependent and -independent signaling through HLA-DR molecules ,Bouillon M, El Fakhry Y, Girouard J, Khalil H, Thibodeau J, Mourad W, J. Biol. Chem. ,PubMed ID 12499388
Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells ,Ivanov A, Beers SA, Walshe CA, Honeychurch J, Alduaij W, Cox KL, Potter KN, Murray S, Chan CH, Klymenko T, Erenpreisa J, Glennie MJ, Illidge TM, Cragg MS, J. Clin. Invest. ,PubMed ID 19620786
Comment on "MHC class II expression identifies functionally distinct human regulatory T cells" ,Swiatek-de Lange M, Rist W, Stahl HF, Weith A, Lenter MC, J. Immunol. ,PubMed ID 18322165
A novel virus capture assay reveals a differential acquisition of host HLA-DR by clinical isolates of human immunodeficiency virus type 1 expanded in primary human cells depending on the nature of producing cells and the donor source ,Cantin R, Martin G, Tremblay MJ, J. Gen. Virol. ,PubMed ID 11714974
Triggering of HLA-DR antigens differentially modulates tumor necrosis factor alpha release by B cells at distinct stage of maturation ,Coral S, Pucillo C, Leonardi A, Fonsatti E, Altomonte M, Maio M, Cell Growth Differ. ,PubMed ID 9149909
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