DC SIGN (CD209) Mouse Monoclonal Antibody [Clone ID: DCN47.5]
CAT#: AM26205PU-N
DC SIGN (CD209) mouse monoclonal antibody, clone DCN47.5, Purified
Conjugation: FITC
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CNY 6,750.00
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Specifications
Product Data | |
Clone Name | DCN47.5 |
Applications | FC, FN |
Recommend Dilution | Flow cytometry: The typical starting working dilution is 1:50. Functional assays: Inhibits binding of DC-SIGN to ICAM-2 on endothelial cells. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Specificity | This antibody reacts with the C-type lectin, DC-SIGN (CD209), exclusively expressed on human dendritic cells (DC). |
Formulation | PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin |
Concentration | lot specific |
Purification | Protein G |
Conjugation | Unconjugated |
Storage Condition | Store at 2 - 8 °C. |
Gene Name | CD209 molecule |
Database Link | |
Background | DC are specialized antigen presenting cells and bridge the innate and the adaptive immune system. They provide high levels of costimulation necessary for activation of both naïve and antigen-experienced T-cells. Immature DC are capable to migrate to inflammatory sites, capture antigen and process it internally to form MHC-peptide complexes. Following antigen uptake, DC undergo maturation and migrate to lymphoid organs where they can present MHC-peptide complexes to resting T-cells and drive T-cell proliferation. During differentiation and maturation of DC, several phenotypic surface markers are expressed: CD1a, CD4, CD11, CD40, CD86, and HLA-DR. Immature DC predominantly express CCR5 which enables DC to migrate to inflammatory sites, whereas mature DC express high levels of CXCR4, a receptor that facilitates migration to lymphoid organs. |
Synonyms | DCSIGN1, DCSIGN, DC-SIGN1, CLEC4L, Dendritic Cell Marker |
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