Cd247 Hamster Monoclonal Antibody [Clone ID: H146-968]

Specifications

Product Data
Clone Name	H146-968
Applications	FC, IF
Recommend Dilution	This clone (H146-968) has been reported to work in Flow Cytometry (in permeabilized cells), Western Blotting and ELISA.
Reactivity	Human, Mouse
Host	Hamster
Clonality	Monoclonal
Immunogen	Synthetic peptide KLH conjugated corresponding to amino acids 151-164 of Mouse CD3 zeta
Specificity	This antibody detects the zeta chain subunit of the T cell receptor (TCR)(CD247).
Formulation	PBS containing 0.02% Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml. State: Purified State: Liquid purified Ig fraction. Label: Biotin
Concentration	lot specific
Purification	Protein G Affinity Chromatography.
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD247 antigen
Database Link	Entrez Gene 919 HumanEntrez Gene 12503 Mouse UniProt ID P24161
Background	The TCR complex consists of a ligand specific alpha/beta heterodimer non-covalently associated with five invariant chains including the CD3 gamma, delta, eta and zeta subunits. This complex regulates assembly and expression of the receptor and is thought to be responsible for transmembrane transduction of signals after binding to TCRαβ. Studies have suggested that the CD3z subunit (also know as CD247) plays an important role in two distinct cellular compartments. In the cytoplasm, it may function to regulate Ag receptor expression and in the plasma membrane it may be required for optimal signaling by the physiologic ligand Ag/MHC. The CD3z subunit is also associated with the CD16 IgG Fc receptor on NK cells.
Synonyms	T3Z, TCRZ, CD3 zeta chain
Reference Data

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