ENPP3 Mouse Monoclonal Antibody [Clone ID: NP4D6]

Specifications

Product Data
Clone Name	NP4D6
Applications	FC, IF
Recommend Dilution	Immunocytochemistry. Flow Cytometry: 1-4 µg/ml. Intracellular and Extracellular staining.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	HEK-293 cells transfected with Human CD203c
Specificity	This Monoclonal antibody NP4D6 reacts with CD203c, a transmembrane ectoenzyme expressed on basophils and mast cells, and overexpressed upon their activation.
Formulation	Phosphate buffered saline (PBS), pH~7.4 with 15 mM Sodium Azide as preservative State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	ectonucleotide pyrophosphatase/phosphodiesterase 3
Database Link	Entrez Gene 5169 Human UniProt ID O14638
Background	CD203c, also known as ENPP-3, is integral membrane ectoenzyme (ectonucleotide pyrophosphatase/phosphodiesterase 3), that hydrolyses nucleotide triphosphates and thus modulates purinergic signaling. CD203c is expressed mainly on activated basophils and mast cells. CD203c is upregulated in response to IgE-receptor cross-linking and is overexpressed on neoplastic mast cells in patients with systemic mastocytosis. Measurement of its induced enhancement on the plasma membrane is useful for diagnostics of allergies.
Synonyms	E-NPP 3, PDNP3, Phosphodiesterase I beta, PD-I beta
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Metabolic pathways, Nicotinate and nicotinamide metabolism, Pantothenate and CoA biosynthesis, Purine metabolism, Riboflavin metabolism, Starch and sucrose metabolism

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