ENPP3 Mouse Monoclonal Antibody [Clone ID: NP4D6]
CAT#: AM12003PE-N
ENPP3 mouse monoclonal antibody, clone NP4D6, PE
Conjugation: Unconjugated APC FITC
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CNY 4,340.00
Specifications
Product Data | |
Clone Name | NP4D6 |
Applications | FC, IF |
Recommend Dilution | Flow Cytometry analysis of Human blood cells using 20 µl reagent/100 ml of whole blood or 10e6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests. Immunofluorescence. |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | HEK-293 cells transfected with Human CD203c |
Specificity | The antibody NP4D6 reacts with CD203c, a transmembrane ectoenzyme expressed on basophils and mast cells, and overexpressed upon their activation. |
Formulation | PBS Label: PE State: Liquid purified Ig fraction Stabilizer: 0.2% high-grade protease free BSA as a stabilizing agent Preservative: 15 mM Sodium Azide Label: Conjugated with R-Phycoerythrin under optimum conditions |
Purification | Size-Exclusion Chromatography |
Conjugation | PE |
Storage Condition | Store the antibody undiluted at 2-8°C. DO NOT FREEZE!. This antibody is photosensitive and should be protected from light. |
Gene Name | ectonucleotide pyrophosphatase/phosphodiesterase 3 |
Database Link | |
Background | CD203c, also known as ENPP-3, is integral membrane ectoenzyme (ectonucleotide pyrophosphatase/phosphodiesterase 3), that hydrolyses nucleotide triphosphates and thus modulates purinergic signaling. CD203c is expressed mainly on activated basophils and mast cells. CD203c is upregulated in response to IgE-receptor cross-linking and is overexpressed on neoplastic mast cells in patients with systemic mastocytosis. Measurement of its induced enhancement on the plasma membrane is useful for diagnostics of allergies. |
Synonyms | E-NPP 3, PDNP3, Phosphodiesterase I beta, PD-I beta |
Reference Data | |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Metabolic pathways, Nicotinate and nicotinamide metabolism, Pantothenate and CoA biosynthesis, Purine metabolism, Riboflavin metabolism, Starch and sucrose metabolism |
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