MHC Class II I-Ab Mouse Monoclonal Antibody [Clone ID: 25-9-3]

Specifications

Product Data
Clone Name	25-9-3
Applications	FC, FN
Recommend Dilution	Flow Cytometry. Complement-dependent Cytotoxicity Assays.
Reactivity	Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	C3H.SW splenocytes. (Ref.1)
Specificity	This antibody reacts specifically with the I-Ab haplotype of MHC Class II molecules. Class II antigens are predominantly expressed on antigen-presenting cells including B lymphocytes, macrophages, dendritic cells and certain epithelial cells.
Formulation	100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Database Link	UniProt ID P18468
Background	MHC Class II antigens are involved in antigen presentation by Antigen Presenting Cells (APCs) to CD4+ T cells. They are constitutively expressed on APCs including B cells, macrophages, monocytes and dendritic cells, and are inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma. The Mouse H2 Ab locus is orthologous to human DQB, which varies from typical class II genes in that both the alpha and beta chains are polymorphic.
Synonyms	H2-Eb1, H-2 class II histocompatibility antigen I-A beta chain
Reference Data

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