MHC Class II I-Ab Mouse Monoclonal Antibody [Clone ID: 25-9-3]

Specifications

Product Data
Clone Name	25-9-3
Applications	FC
Recommend Dilution	Flow Cytometry: < / = 0.2 µg/10e6 cells.
Reactivity	Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	C3H.SW splenocytes. (Ref.1)
Specificity	This antibody reacts specifically with the I-Ab haplotype of MHC Class II molecules. Class II antigens are predominantly expressed on antigen-presenting cells including B lymphocytes, macrophages, dendritic cells and certain epithelial cells.
Formulation	PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent. Label: PE State: Liquid purified Ig fraction. Label: R-Phycoerythrin
Concentration	lot specific
Conjugation	PE
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Database Link	UniProt ID P18468
Background	MHC Class II antigens are involved in antigen presentation by Antigen Presenting Cells (APCs) to CD4+ T cells. They are constitutively expressed on APCs including B cells, macrophages, monocytes and dendritic cells, and are inducible on a number of other cells (endothelium and epithelial cells) by interferon gamma. The Mouse H2 Ab locus is orthologous to human DQB, which varies from typical class II genes in that both the alpha and beta chains are polymorphic.
Synonyms	H2-Eb1, H-2 class II histocompatibility antigen I-A beta chain
Reference Data

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