Cd72 (CD72.1 alloantigen) Mouse Monoclonal Antibody [Clone ID: 10-1.D.2]

Specifications

Product Data
Clone Name	10-1.D.2
Applications	FC, FN
Recommend Dilution	Flow Cytometry. (Ref.1,2) Functional Assays: In vitro blocking and proliferation assays. (Ref.2,3)
Reactivity	Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	DBA/2 mouse spleen cells. (Ref.1)
Specificity	This antibody recognises CD72.1/Lyb-2.1 (Mr. 45 kDa). It blocks binding of CD5 to CD72 on the B cell surface, which leads to inhibition of the positive signal resulting from CD5/CD72 pairing. (Ref.1) However, 10-1.D.2 can itself trigger a positive signal by binding CD72. (Ref.1-5)
Formulation	100 mM Borate Buffered Saline, pH 8.2. No preservatives or amine-containing buffer salts added. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD72 antigen
Database Link	Entrez Gene 12517 Mouse UniProt ID P21855
Background	Murine CD72.1/Lyb-2.1, a type II integral membrane glycoprotein and a member of the C-lectin family of cell surface receptors, is a differentiation antigen of B cells, and is found in mouse strains expressing the Lyb-2.1 allotype. CD72.1 is the ligand of CD5 (Ly-1) which is distributed on all T cells and a small number of B cells. (Ref.1,2)
Synonyms	Lyb-2, Ly-32, Ly32, B-Cell marker
Reference Data

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